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Predictors of ongoing implantation in IVF in a good prognosis group of patients
Department of Reproductive Medicine, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Fertility Centre of Scandinavia, Carlanderska Hospital, Göteborg, Sweden.
Fertility Clinic, Haugesund Hospital, Haugesund, Norway.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Molecular and Clinical Medicine.
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2005 (English)In: Human Reproduction, ISSN 0268-1161, Vol. 20, no 7, 1876-1880 p.Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this study was to investigate whether, in a large randomized trial, it is possible to identify specific maternal and/or embryo variables that could independently correlate with ongoing implantation in IVF/ICSI. Methods: In a Scandinavian study, 661 women were randomized to elective single embryo transfer or double embryo transfer. Women aged <36 years undergoing their first or second IVF cycle and with at least two good quality embryos were eligible. Only one cycle per subject was included. In the present study, cycles with 0 or 100% ongoing implantation (n = 520) were analysed regarding maternal and embryo variables. Results: In this selected study group, the ongoing implantation rate was 195/734 (26.6%). In the univariate analysis, first IVF cycle, conventional IVF as fertilization method and 4-cell embryos showed a statistically higher ongoing implantation rate than did second IVF cycle, ICSI and non-4-cell embryos. In the multivariate analysis the same variables correlated independently to ongoing implantation. In addition, ovarian sensitivity correlated independently to ongoing implantation. Conclusion: This information should be used when selecting the number of embryos for transfer with the overall aim to reduce the rate of multiple births while maintaining a satisfactory birth rate. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.

Place, publisher, year, edition, pages
2005. Vol. 20, no 7, 1876-1880 p.
Keyword [en]
Embryo selection, Ongoing implantation, Prediction of IVF outcome, Randomized controlled trial
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-50474DOI: 10.1093/humrep/deh872OAI: diva2:271370
Available from: 2009-10-11 Created: 2009-10-11 Last updated: 2011-01-12

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Jablonowska, Barbara
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Faculty of Health SciencesDepartment of Molecular and Clinical Medicine
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