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The role of statins in the prevention of ischemic stroke
Linköping University, Department of Medicine and Health Sciences, Internal Medicine . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Internal Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Endocrinology and Gastroenterology.
2005 (English)In: Current Atherosclerosis Reports, ISSN 1523-3804, E-ISSN 1534-6242, Vol. 7, no 5, 364-368 p.Article in journal (Refereed) Published
Abstract [en]

Statin treatment has been demonstrated to diminish the risk for stroke in patients with coronary heart disease, hypercholesterolemia, normocholesterolemia, in the elderly, and among hypertensive and diabetic patients. Stroke incidence in patients on statin treatment has been reduced in all these clinical settings involving both primary and secondary prevention but not in patients with previous stroke. Two recent meta-analyses confirm this conclusion. The mechanism by which statins provide benefit against stroke is likely multifactorial, involving both the low-density lipoprotein cholesterol-lowering effect with stabilization of vulnerable plaques, and pleiotropic effects such as improvement of endothelial function, increased nitric oxide bioavailability, antioxidant properties, inhibition of inflammatory responses, immunomodulatory actions, and regulation of progenitor cells.

Place, publisher, year, edition, pages
2005. Vol. 7, no 5, 364-368 p.
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Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-51029DOI: 10.1007/s11883-005-0048-7OAI: oai:DiVA.org:liu-51029DiVA: diva2:272557
Available from: 2009-10-15 Created: 2009-10-15 Last updated: 2017-12-12

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Ziedén, BoOlsson, Anders

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Internal Medicine Faculty of Health SciencesDepartment of Endocrinology and Gastroenterology
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