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The Contractility of Isolated Rat Atrial Tissue during Hypoxia is Better Preserved in a High- or Zero-glucose Environment than in a Normal Glucose Environment
Linköping University, Department of Medicine and Health Sciences, Thoracic Surgery. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Thoracic and Vascular Surgery.
Östergötlands Läns Landsting. (Landstinget i Östergötland)
Östergötlands Läns Landsting. (Landstinget i Östergötland)
Linköping University, Department of Medicine and Health Sciences, Pharmacology . Linköping University, Faculty of Health Sciences.
2009 (English)In: International Journal of Biomedical Sciences, ISSN 1306-1216, Vol. 5, no 1, 12-16 p.Article in journal (Refereed) Published
Abstract [en]

Aim: Hyperglycemia is known to be associated with an increase in mortality in myocardial infarction and intensive care patients despite the fact that glucose metabolism plays a central role in myocardial protection. We studied the effect of different glucose levels (22 Mm L-1; 5.5 mM L-1; and 0 mM L-1) on the contractile reserve of isolated rat atrial myocardium during and after hypoxia.Methods: We observed the contraction ofisolated rat atrium strips caused by electrical-field stimulation in a modified Krebs-Henseleit Buffer (KHB) organ bath oxygenated with 95% O2 + 5% CO2 at 37°C. We applied two periods of hypoxia and two periods of reoxygenation. Three glucose concentrations were used in the buffer to study the effect of glucose (high- n=6; normal- n=7; and zero-glucose n=6). The effect of isoproterenol 1 µM L-1 was tested during the second ischemic period.Results: The main finding was that both a zero-glucose (27.8 ± 5.9 vs. 14.7 ± 3 % of baseline tension) and a high-glucose environment (38.5 ± 14 vs. 14.7 ± 3 % of baseline tension) had a positive effect in terms of better contractility than the normal-glucose buffer during both the first (p=0.00062) and the second ischemic period (31.2 ± 5.9 % zero-glucose vs 14.7 ± 4.2 normal-glucose vs. 35.3 ± 15.9% high-glucose p=0.0038).Conclusion: Both zero-glucose and high-glucose environments resulted in a better contractile reserve in isolated rat atrial myocardium during hypoxia than in a normal one. The exact clinical relevance of this observation is, at present, unclear.

Place, publisher, year, edition, pages
2009. Vol. 5, no 1, 12-16 p.
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Medical and Health Sciences
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URN: urn:nbn:se:liu:diva-51093OAI: oai:DiVA.org:liu-51093DiVA: diva2:272754
Available from: 2009-10-16 Created: 2009-10-16 Last updated: 2017-12-12

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Szabó, ZoltánAndersson, Rolf

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Thoracic SurgeryFaculty of Health SciencesDepartment of Thoracic and Vascular SurgeryÖstergötlands Läns LandstingPharmacology
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