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Increased Prevalence of Anti-gliadin Antibodies and Anti-tissue Transglutaminase Antibodies in Children With Cerebral Palsy
Örebro University Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences, Engelska: Faculty of Health Sciences, Medical Programme. Östergötlands Läns Landsting, Centre for Laboratory Medicine.
Örebro University Hospital.
Örebro University Hospital.
2009 (English)In: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, ISSN 0277-2116, Vol. 49, no 4, 424-429 p.Article in journal (Refereed) Published
Abstract [en]

Aim and Objective: The aim of the study was to investigate whether there is any association between cerebral palsy (CP) and celiac disease(CD) in children. Patients and Methods: Ninety children between 18 months and 18 years of age (median 9 years) with CP were included. Antibodies (IgA and IgG) against gliadin (AGA), endomysium (EMA), and tissue transglutaminase (tTG) were measured. Children with elevated levels of these antibodies were offered a small-bowel biopsy. Results: Thirty-nine children showed an elevated level of 1 or more of the tested antibodies (43%). None had raised EMA antibodies. Presence of tetraplegia or dyskinesia was associated with increased antibody levels (P=0.045), as was a more severe functional type of CP (P=0.008). Children with elevated antibodies had a lower body weight (P=0.049), height (P=0.041), and body mass index (BMI) (P=0.014). Small-bowel biopsies were performed in 27 out of 39 children; 1 had CD and 2 had intraepithelial lymphocytosis. Conclusions: A large number of children with CP had elevated AGA and/or anti-tTG. Because these elevations were associated with lower weight, height, and BMI, it seemed of interest to speculate on how these findings correlated to CP and CD. However, we found no correlation between CP and CD.

Place, publisher, year, edition, pages
2009. Vol. 49, no 4, 424-429 p.
Keyword [en]
Antibodies to tissue transglutaminase, Antigliadin IgG and IgA antibodies, Celiac disease, Cerebral palsy, Small-bowel biopsy
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-51260DOI: 10.1097/MPG.0b013e31819a4e52OAI: diva2:273899
Available from: 2009-10-26 Created: 2009-10-26 Last updated: 2014-09-09

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Dahle, Charlotte
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Clinical ImmunologyEngelska: Faculty of Health Sciences, Medical ProgrammeCentre for Laboratory Medicine
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