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Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
Linköping University, Faculty of Health Sciences. Linköping University, Department of Medicine and Care, Pharmacology.
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1989 (English)In: Agents and actions, ISSN 0065-4299, Vol. 27, no 1-2, 25-28 p.Article in journal (Refereed) Published
Abstract [en]

Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.

Place, publisher, year, edition, pages
1989. Vol. 27, no 1-2, 25-28 p.
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Pharmacology and Toxicology
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URN: urn:nbn:se:liu:diva-21013DOI: 10.1007/BF02222188PubMedID: 2473625OAI: oai:DiVA.org:liu-21013DiVA: diva2:275174
Available from: 2009-11-03 Created: 2009-09-28 Last updated: 2009-11-09

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Andersson, Rolf GLindström, EvaToll, Johan B

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