Studies of the mechanism of desensitization of anti-IgE-mediated histamine release from human basophils
1989 (English)In: Agents and actions, ISSN 0065-4299, Vol. 27, no 1-2, 25-28 p.Article in journal (Refereed) Published
Human basophils became hyporesponsive to anti-IgE when exposed to this agent in the absence of Ca2+ for more than 10 min. The desensitization process proceeded in parallel to the releasing-process. The mechanism of desensitization seems to involve a very early step in the release-reaction, since the response to phospholipase A2 and diolein, agents involved in the release-reaction, was not affected by the desensitization.
Place, publisher, year, edition, pages
1989. Vol. 27, no 1-2, 25-28 p.
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:liu:diva-21013DOI: 10.1007/BF02222188PubMedID: 2473625OAI: oai:DiVA.org:liu-21013DiVA: diva2:275174