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Artificial corneas: a regenerative medicine approach
University of Ottawa.ORCID iD: 0000-0003-1222-6720
University of Ottawa.
Linköping University, Department of Clinical and Experimental Medicine, Ophthalmology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of Ophthalmology UHL/MH. (Landstinget i Östergötland)
University of Ottawa.
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2009 (English)In: EYE, ISSN 0950-222X, Vol. 23, no 10, 1985-1989 p.Article in journal (Refereed) Published
Abstract [en]

Corneal substitutes are being developed to address the shortage of human donor tissues as well as the current disadvantages in some clinical indications, which include immune rejection. In the past few years, there have been significant developments in bioengineered corneas that are designed to replace part or the full thickness of damaged or diseased corneas that range from keratoprostheses that solely address the replacement of the corneas function, through tissue-engineered hydrogels that permit regeneration of host tissues. We describe examples of corneal substitutes that encourage regeneration of the host tissue. We also contend that it is unlikely that there will be a single "one-size-fits-all corneal substitute for all indications. Instead, there will most likely be a small range of corneal substitutes ranging from prostheses to tissue-engineered matrix substitutes that are tailored to different clusters of clinical indications. The tissue-engineered matrices can either be produced as sterile acellular matrices, or complete with functional cells, ready for implantation.

Place, publisher, year, edition, pages
2009. Vol. 23, no 10, 1985-1989 p.
Keyword [en]
corneal substitutes, transplantation, regeneration
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-51482DOI: 10.1038/eye.2008.409OAI: oai:DiVA.org:liu-51482DiVA: diva2:275297
Available from: 2009-11-04 Created: 2009-11-04 Last updated: 2013-12-17

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Griffith, MayLagali, NeilFagerholm, Per

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