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The Discovery of Cellular Immunity in the Atherosclerotic Plaque
Karolinska Institute.
Linköping University, Department of Medicine and Health Sciences, Cardiology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Heart Centre, Department of Cardiology.
2009 (English)In: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, Vol. 29, no 11, 1714-1717 p.Article in journal (Refereed) Published
Abstract [en]

It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.

Place, publisher, year, edition, pages
2009. Vol. 29, no 11, 1714-1717 p.
Keyword [en]
athersclerosis, immunity, inflammation, cytokines, T cells, macrophages
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-51486DOI: 10.1161/ATVBAHA.108.179713OAI: diva2:275302
Available from: 2009-11-04 Created: 2009-11-04 Last updated: 2009-11-04

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Jonasson, Lena
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Cardiology Faculty of Health SciencesDepartment of Cardiology
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