liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The effect of transvaginal estradiol on bone in aged women; a randomised controlled trial
Karolinska institutet, Stockholm.
Karolinska institutet, Stockholm.
Karolinska institutet.
Karolinska institutet, Stockholm.ORCID iD: 0000-0001-9531-7892
Show others and affiliations
2007 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 57, 370-381 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the effect of transvaginal estradiol on bone mineral density and bone metabolism.

Methods: One hundred and fifteen women (mean age 73.8 ± 3.2 years) were randomly assigned to a 2-year open-label parallel group clinical trial and were treated with either transvaginal estradiol (7.5 μg/24 h), or no estradiol. Both groups received 400 IU vitamin D and 500 mg calcium/day. The bone mineral density (BMD) was assessed in the hip and spine using DXA technique and in the heel using DXL technique.

Results: The intention to treat analysis showed that the increase in BMD in the estradiol group was significant at total hip by 0.6% (P = 0.04) while the control group decreased in their BMD by 0.7%. At lumbar spine the estradiol group increased in BMD by 2.6% (P = 0.011) while the control group increased by 2.2%. Bone turnover markers and PTH-levels decreased while 25-OH vitamin D levels increased in both groups, a probable effect of the calcium and vitamin D supplementation. The bone resorption marker CTx decreased more significantly in the treatment group (P = 0.016).

Conclusions: The transvaginal estradiol treatment of 7.5 μg/24 h had a small but significant effect on the BMD of total hip and lumbar spine after a follow-up of 2 years.

Place, publisher, year, edition, pages
Ireland: Elsevier Ireland Ltd , 2007. Vol. 57, 370-381 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-51562DOI: 10.1016/j.maturitas.2007.03.005PubMedID: 17493777OAI: oai:DiVA.org:liu-51562DiVA: diva2:275722
Available from: 2009-11-06 Created: 2009-11-06 Last updated: 2013-09-03

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Authority records BETA

Ringertz, Hans

Search in DiVA

By author/editor
Ringertz, Hans
In the same journal
Maturitas
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf