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The effect of transvaginal estradiol on bone in aged women; a randomised controlled trial
Karolinska institutet, Stockholm.
Karolinska institutet, Stockholm.
Karolinska institutet.
Karolinska institutet, Stockholm.ORCID iD: 0000-0001-9531-7892
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2007 (English)In: Maturitas, ISSN 0378-5122, E-ISSN 1873-4111, Vol. 57, 370-381 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate the effect of transvaginal estradiol on bone mineral density and bone metabolism.

Methods: One hundred and fifteen women (mean age 73.8 ± 3.2 years) were randomly assigned to a 2-year open-label parallel group clinical trial and were treated with either transvaginal estradiol (7.5 μg/24 h), or no estradiol. Both groups received 400 IU vitamin D and 500 mg calcium/day. The bone mineral density (BMD) was assessed in the hip and spine using DXA technique and in the heel using DXL technique.

Results: The intention to treat analysis showed that the increase in BMD in the estradiol group was significant at total hip by 0.6% (P = 0.04) while the control group decreased in their BMD by 0.7%. At lumbar spine the estradiol group increased in BMD by 2.6% (P = 0.011) while the control group increased by 2.2%. Bone turnover markers and PTH-levels decreased while 25-OH vitamin D levels increased in both groups, a probable effect of the calcium and vitamin D supplementation. The bone resorption marker CTx decreased more significantly in the treatment group (P = 0.016).

Conclusions: The transvaginal estradiol treatment of 7.5 μg/24 h had a small but significant effect on the BMD of total hip and lumbar spine after a follow-up of 2 years.

Place, publisher, year, edition, pages
Ireland: Elsevier Ireland Ltd , 2007. Vol. 57, 370-381 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-51562DOI: 10.1016/j.maturitas.2007.03.005PubMedID: 17493777OAI: diva2:275722
Available from: 2009-11-06 Created: 2009-11-06 Last updated: 2013-09-03

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