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Atomoxetine improves patient and family coping in attention deficit/hyperactivity disorder: a randomized, double-blind, placebo-controlled study in Swedish children and adolescents
Eli Lilly Sweden AB.
Lund University.
Linköping University, Department of Clinical and Experimental Medicine, Child and Adolescent Psychiatry . Linköping University, Faculty of Health Sciences.
Umeå University.
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2009 (English)In: EUROPEAN CHILD and ADOLESCENT PSYCHIATRY, ISSN 1018-8827, Vol. 18, no 12, 725-735 p.Article in journal (Refereed) Published
Abstract [en]

This 10-week study assessed the efficacy of atomoxetine in combination with psychoeducation compared to placebo and psychoeducation in the improvement of Quality of Life in Swedish stimulant-naive children and adolescents with attention deficit/hyperactivity disorder. A total of 99 patients were treated with atomoxetine (49 patients) or placebo (50 patients) for 10 weeks and assessed regarding broader areas of functioning using the Quality of Life measures Child Health and Illness Profile-Child Edition (CHIP-CE), Family Strain Index [FSI; equivalent to the Family Burden of Illness Module used in the study], Appraisal of Stress in Child-Rearing (ASCR), Five to fifteen (FTF), "I think I am" ("Jag tycker jag ar"), and Childrens Depression Rating Scale-Revised (CDRS-R) before and after the active treatment phase. Simultaneously, the patients parents participated in a 4-session psychoeducation program. A statistically significant difference in favor of atomoxetine was seen in the improvement from baseline to study endpoint for the CHIP-CE domains "Achievement" and "Risk avoidance", for the FSI total score, for the ASCR section (I) domain "Child as a burden", for all FTF domains except for "Language and Speech", and for the CDRS-R total score. No difference between treatment groups was observed in the patient-assessed evaluation of self-esteem using the "I think I am" scale. Atomoxetine combined with psychoeducation had a positive effect on various everyday coping abilities of the patients as well as their families during 10 weeks of treatment, whereas the patients self-image and the parents image of the climate in the family were not significantly improved.

Place, publisher, year, edition, pages
2009. Vol. 18, no 12, 725-735 p.
Keyword [en]
ADHD, Atomoxetine, Quality of life, CHIP-CE, Broader efficacy
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-51777DOI: 10.1007/s00787-009-0031-xOAI: diva2:277384
Available from: 2009-11-18 Created: 2009-11-17 Last updated: 2009-11-18

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Gustafsson, Per
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