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Standardizing resistive indices in healthy pediatric transplant recipients of adult-sized kidneys
Stanford University.
Stanford University.
Linköping University, Center for Medical Image Science and Visualization (CMIV). Linköping University, Department of Medical and Health Sciences, Radiology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medical Imaging, Department of Radiology in Linköping.ORCID iD: 0000-0001-9531-7892
Stanford University.
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2010 (English)In: Pediatric Transplantation, ISSN 1397-3142, E-ISSN 1399-3046, Vol. 14, no 1, 126-131 p.Article in journal (Refereed) Published
Abstract [en]

Small pediatric recipients of an adult-sized kidney have insufficient renal blood flow early after transplantation, with secondary chronic hypoperfusion and irreversible histological damage of the tubulo-interstitial compartment. It is unknown whether this is reflected by renal resistive indices. We measured renal graft resistive indices and volumes of 47 healthy pediatric kidney transplant recipients of an adult-sized kidney in a prospective study for six months post-transplant. A total of 205 measurements were performed. The smallest recipients (BSA </=0.75 m(2)) had higher resistive indices compared to recipients with a BSA between 0.75 and 1.5 m(2) (p < 0.0001) and to recipients with a BSA >/= 1.5 m(2) (p < 0.0001). Resistive indices increased during the first six months in the smallest recipients (p = 0.02), but not in the two larger recipient groups (BSA 0.75-1.5 m(2) and >/=1.5 m(2)). All three BSA groups showed a reduction in renal volume after transplantation, with the greatest reduction occurring in the smallest recipients. In conclusion, renal transplant resistive indices reflect pediatric recipient BSA dependency. The higher resistance to intra-renal vascular flow and significant decrease in renal volume in the smallest group likely reflect accommodation of the size discrepant transplanted adult-sized kidney to the smaller pediatric recipient vasculature with associated lower renal artery flow.

Place, publisher, year, edition, pages
Denmark: Wiley-Blackwell Munksgaard , 2010. Vol. 14, no 1, 126-131 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-51859DOI: 10.1111/j.1399-3046.2009.01180.xISI: 000273478100024PubMedID: 19413712OAI: diva2:277860
Available from: 2009-11-20 Created: 2009-11-20 Last updated: 2015-10-09

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Ringertz, Hans G
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Center for Medical Image Science and Visualization (CMIV)RadiologyFaculty of Health SciencesDepartment of Radiology in Linköping
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Pediatric Transplantation
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