Incidence of and potential risk factors for gallstone disease in a general population sample
2009 (English)In: BRITISH JOURNAL OF SURGERY, ISSN 0007-1323, Vol. 96, no 11, 1315-1322 p.Article in journal (Refereed) Published
Background: Several epidemiological studies have been published, but there are few reports on relations between gallstone incidence, symptomatology and risk factors. Methods: Of 621 randomly selected individuals aged 35-85 years in a general population who been screened previously, with ultrasonography and found to have no gallbladder stones, 503 (81.0 per cent) were re-examined after a minimum interval of 5 years. At baseline and re-examination, heredity for gallstone disease was explored and body mass index, digestive symptoms including abdominal pain, quality of life, alcohol and smoking habits, use of non-steroidal anti-inflammatory drugs and oestrogen, parity and blood lipid levels were recorded. Results: Forty-two (8.3 per cent) of the 503 subjects developed stones. Subjects were followed for a total of 3025.8 person-years, yielding an incidence for newly developed gallstones of 1.39 per 100 person-years. A positive association for gallstone development,was found only for length of follow-up and plasma low-density lipoprotein-cholesterol levels at baseline. Weekly alcohol consumption was inversely related to gallstone development. Conclusion: The incidence of gallstones in this population was 1.39 per 100 person-years. Gallstone development was related to length of follow-up and LDL-cholesterol levels, and inversely related to alcohol consumption.
Place, publisher, year, edition, pages
2009. Vol. 96, no 11, 1315-1322 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-51895DOI: 10.1002/bjs.6687OAI: oai:DiVA.org:liu-51895DiVA: diva2:278071