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Autoimmune T cell responses to antigenic peptides presented by bronchoalveolar lavage cell HLA-DR molecules in sarcoidosis
Karolinska University Hospital.
University Tubingen.
Karolinska Institute.
University of Oklahoma.
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2009 (English)In: CLINICAL IMMUNOLOGY, ISSN 1521-6616, Vol. 133, no 3, 353-363 p.Article in journal (Refereed) Published
Abstract [en]

The etiology of sarcoidosis remains unknown. Recently, by mass spectrometric sequencing of peptides eluted from HLA-DR molecules of bronchoalveolar lavage (BAL) cells from DRB1*0301(pos) patients, we identified potential self-antigens in sarcoidosis. The aim of the present study was to investigate the capacity of selected peptides to stimulate tung and blood T cells of sarcoidosis patients using an interferon-gamma ELISPOT assay. In peripheral blood, there were strong T cell responses to a peptide derived from the cytoskeletal protein vimentin in 6 out of 11 DRBI*0301(pos) patients with active disease but not in patients with other HLA types. BAL T cell responses against peptides derived from ATP synthase or from lysyl-tRNA synthetase were detected in DRB1*0301(pos) as welt as DRB1*0301(neg) patients. By using antigenic peptides presented in vivo in the lungs of sarcoidosis patients, we have identified blood and lung T cell autoimmune responses that may help sustain the inflammation in this disease.

Place, publisher, year, edition, pages
2009. Vol. 133, no 3, 353-363 p.
Keyword [en]
Sarcoidosis, Interstitial lung disease, Bronchoalveolar lavage, Antigen, Autoantigen, T cell, HLA-DR, Peptide
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-52383DOI: 10.1016/j.clim.2009.08.008OAI: diva2:282199
Available from: 2009-12-18 Created: 2009-12-18 Last updated: 2009-12-18

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