liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Cited2 Is an Essential Regulator of Adult Hematopoietic Stem Cells
University of Oxford, UK.
University of Oxford, UK.
University of Oxford, UK.
Newcastle University, UK.
Show others and affiliations
2009 (English)In: Cell Stem Cell, ISSN 1934-5909, Vol. 5, no 6, 659-665 p.Article in journal (Refereed) Published
Abstract [en]

The regulatory pathways necessary for the maintenance of adult hematopoietic stem cells (HSCs) remain poorly defined. By using loss-of-function approaches, we report a selective and cell-autonomous requirement for the p300/CBP-binding transcriptional coactivator Cited2 in adult HSC maintenance. Conditional deletion of Cited2 in the adult mouse results in loss of HSCs causing multilineage bone marrow failure and increased lethality. In contrast, conditional ablation of Cited2 after lineage specification in lymphoid and myeloid lineages has no impact on the maintenance of these lineages. Additional deletion of Ink4a/Arf (encoding p16Ink4a and p19Arf) or Trp53 (encoding p53, a downstream target of p19Arf) in a Cited2-deficient background restores HSC functionality and rescues mice from bone marrow failure. Furthermore, we show that the critical role of Cited2 in primitive hematopoietic cells is conserved in humans. Taken together, our studies provide genetic evidence that Cited2 selectively maintains adult HSC functions, at least in part, via Ink4a/Arf and Trp53.

Place, publisher, year, edition, pages
2009. Vol. 5, no 6, 659-665 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-52615DOI: 10.1016/j.stem.2009.11.001OAI: oai:DiVA.org:liu-52615DiVA: diva2:284298
Available from: 2010-01-05 Created: 2010-01-05 Last updated: 2010-02-01

Open Access in DiVA

No full text

Other links

Publisher's full text

Authority records BETA

Sigvardsson, Mikael

Search in DiVA

By author/editor
Sigvardsson, Mikael
By organisation
Cell BiologyFaculty of Health Sciences
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 28 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf