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Nano-fiber scaffold electrodes based on PEDOT for cell stimulation
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Karolinska Institute.
Linköping University, Department of Physics, Chemistry and Biology, Biomolecular and Organic Electronics. Linköping University, The Institute of Technology.
Industrial Research & Development Corporation.
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2009 (English)In: SENSORS AND ACTUATORS B-CHEMICAL, ISSN 0925-4005, Vol. 142, no 2, 451-456 p.Article in journal (Refereed) Published
Abstract [en]

Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling.

Place, publisher, year, edition, pages
2009. Vol. 142, no 2, 451-456 p.
Keyword [en]
Poly(ethylenedioxythiophene) (PEDOT), Electrospinning, Poly(ethylene terephthalate) (PET), Cell stimulation, SH-SY5Y neuroblastoma cells, Nano-fibers
National Category
Natural Sciences
URN: urn:nbn:se:liu:diva-52395DOI: 10.1016/j.snb.2009.04.062OAI: diva2:285049
Original Publication: Maria Bolin, Karl Svennersten, Xiangjun Wang, Ioannis S Chronakis, Agneta Richter-Dahlfors, Edwin Jager and Magnus Berggren, Nano-fiber scaffold electrodes based on PEDOT for cell stimulation, 2009, SENSORS AND ACTUATORS B-CHEMICAL, (142), 2, 451-456. Copyright: Elsevier Science B.V., Amsterdam. Available from: 2010-01-11 Created: 2009-12-18 Last updated: 2015-05-06
In thesis
1. Conjugated Polymer Surface Switches for Active Control
Open this publication in new window or tab >>Conjugated Polymer Surface Switches for Active Control
2011 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Conjugated polymers have been found useful in a wide range of applications such as sensors, electrochemical transistors, solar cells, and printed electronics due to their mechanical, optical and electronic properties. An amazing research field has grown during the last three decades since the discovery of conducting polymers in 1976. Since the materials can be made from solutions, different processing methods such as spin coating and vapor phase polymerization can be used to coat a huge variety of substrates. The choice of method depends mainly on monomer solubility and kind of substrate to be coated. During the synthesis the polymers can be chemically modified to tailor their functionalities. Due to this variability in materials and the processability, electronics can be achieved on unconventional substrates such as flexible plastic foils and cell culturing dishes. As a contrast to inorganic, usually metallic materials, conducting polymers are built up from organic compounds in a molecular structure with soft mechanical properties that have shown to be a benefit in combination with biology, ranging from interactions with cells to interactions with advanced biological species such as tissues. This combination of research fields and the possible applications are merged within the field of organic bioelectronics.

The primary purpose of this thesis is to give a background to organic electronics in general and how electrochemical devices can be processed and developed for biological applications in particular. An organic electronic surface switch is introduced to control cell adhesion and proliferation as well as an electrochemical transistor to spatially tune the cell adhesion along an electrochemical gradient. To mimic a more natural cell environment a three dimensional fiber substrate was used to design an electronically active matrix to promote nerve cell adhesion and communication. By combining standard microfabrication techniques and conjugated polymers desired patterns of electroactive polymer were created to enable active regulation of cell populations and their extracellular environment at high spatial resolution. Finally, a brief look into future challenges will also be presented.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2011. 52 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1398
National Category
Natural Sciences
urn:nbn:se:liu:diva-71361 (URN)978-91-7393-063-5 (ISBN)
Public defence
2011-10-21, K3, Kåkenhus, Campus Norrköping, Linköpings universitet, Norrköping, 13:15 (English)
Available from: 2011-10-13 Created: 2011-10-13 Last updated: 2015-05-06Bibliographically approved

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