Nano-fiber scaffold electrodes based on PEDOT for cell stimulation
2009 (English)In: SENSORS AND ACTUATORS B-CHEMICAL, ISSN 0925-4005, Vol. 142, no 2, 451-456 p.Article in journal (Refereed) Published
Electronically conductive and electrochemically active 3D-scaffolds based on electrospun poly(ethylene terephthalate) (PET) nano-fibers are reported. Vapour phase polymerization was employed to achieve an uniform and conformal coating of poly(3,4-ethylenedioxythiophene) doped with tosylate (PEDOT:tosylate) on the nano-fibers. The PEDOT coatings had a large impact on the wettability, turning the hydrophobic PET fibers super-hydrophilic. SH-SY5Y neuroblastoma cells were grown on the PEDOT coated fibers. The SH-SY5Y cells adhered well and showed healthy morphology. These electrically active scaffolds were used to induce Ca2+ signalling in SH-SY5Y neuroblastoma cells. PEDOT:tosylate coated nano-fibers represent a class of 3D host environments that combines excellent adhesion and proliferation for neuronal cells with the possibility to regulate their signalling.
Place, publisher, year, edition, pages
2009. Vol. 142, no 2, 451-456 p.
Poly(ethylenedioxythiophene) (PEDOT), Electrospinning, Poly(ethylene terephthalate) (PET), Cell stimulation, SH-SY5Y neuroblastoma cells, Nano-fibers
National CategoryNatural Sciences
IdentifiersURN: urn:nbn:se:liu:diva-52395DOI: 10.1016/j.snb.2009.04.062OAI: oai:DiVA.org:liu-52395DiVA: diva2:285049
Maria Bolin, Karl Svennersten, Xiangjun Wang, Ioannis S Chronakis, Agneta Richter-Dahlfors, Edwin Jager and Magnus Berggren, Nano-fiber scaffold electrodes based on PEDOT for cell stimulation, 2009, SENSORS AND ACTUATORS B-CHEMICAL, (142), 2, 451-456.
Copyright: Elsevier Science B.V., Amsterdam.