Cover Image: Colorimetric sensing: Small 21/2009.
2009 (English)Other (Refereed)
The cover picture illustrates a novel concept for colorimetric protein sensing based on the controllable assembly of polypeptide-functionalized gold nanoparticles. Recognition of the analyte is accomplished by polypeptide-based synthetic receptors immobilized on gold nanoparticles. Also present on the particle surface is a de novo-designed helix-loop-helix polypeptide that homodimerizes and folds into four-helix bundles in the presence of Zn2+, resulting in particle aggregation. Analyte binding interferes with the folding-induced aggregation, giving rise to a clearly detectable colorimetric response.
Place, publisher, year, edition, pages
2009. Vol. 5, no 21
IdentifiersURN: urn:nbn:se:liu:diva-53089DOI: 10.1002/smll.200990103PubMedID: 19866478OAI: oai:DiVA.org:liu-53089DiVA: diva2:286691