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Cover Image: Colorimetric sensing: Small 21/2009.
Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics. Linköping University, The Institute of Technology.ORCID iD: 0000-0002-7001-9415
Linköping University, Department of Physics, Chemistry and Biology, Molecular Physics. Linköping University, Faculty of Science & Engineering.
Uppsala University .
Linköping University, Department of Physics, Chemistry and Biology, Sensor Science and Molecular Physics. Linköping University, The Institute of Technology.
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2009 (English)Other (Refereed)
Abstract [en]

The cover picture illustrates a novel concept for colorimetric protein sensing based on the controllable assembly of polypeptide-functionalized gold nanoparticles. Recognition of the analyte is accomplished by polypeptide-based synthetic receptors immobilized on gold nanoparticles. Also present on the particle surface is a de novo-designed helix-loop-helix polypeptide that homodimerizes and folds into four-helix bundles in the presence of Zn2+, resulting in particle aggregation. Analyte binding interferes with the folding-induced aggregation, giving rise to a clearly detectable colorimetric response.

Place, publisher, year, pages
2009. Vol. 5, no 21
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Natural Sciences
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URN: urn:nbn:se:liu:diva-53089DOI: 10.1002/smll.200990103PubMedID: 19866478OAI: oai:DiVA.org:liu-53089DiVA: diva2:286691
Available from: 2010-01-15 Created: 2010-01-15 Last updated: 2015-05-29

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Aili, DanielSelegård, RobertEnander, KarinLiedberg, Bo

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