liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
Comparison of lycopene and fluvastatin effects on atherosclerosis induced by a      high-fat diet in rabbits
School of Public Health, Central South University, Changsha, China.
School of Public Health, Central South University, Changsha, China.
bMedical College of Hunan Normal University, Changsha, China. (Sivert Lindström)
School of Public Health, Central South University, Changsha, China.
Show others and affiliations
2008 (English)In: Nutrition Journal, ISSN 1475-2891, Vol. 24, no 10, 1030-1038 p.Article in journal (Refereed) Published
Abstract [en]

We evaluated the antiatherogenic effect of lycopene in rabbits fed a high-fat diet.


Forty adult male rabbits were divided into five groups that were fed a standard diet, a high-fat diet, a high-fat diet plus 4 mg/kg of lycopene, a high-fat diet plus 12 mg/kg of lycopene, and a high-fat diet plus 10 mg/kg of fluvastatin, respectively. Lycopene and fluvastatin were administered intragastrically. The level of serum total cholesterol, total triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, total antioxidant capacity, and malondialdehyde were measured before and after 4 and 8 wk of experimental treatment. In addition, plasma levels of lycopene, oxidized low-density lipoprotein, serum nitric oxide, and interleukin-1 were measured after the experiment. The area of atherosclerotic plaque and pathologic changes of the aorta were evaluated.


Compared with the control, levels of total cholesterol, total triacylglycerol, low-density lipoprotein cholesterol, malonaldehyde, oxidized low-density lipoprotein, and interleukin-1 were increased and total antioxidant capacity and nitric oxide were decreased in the animals with a high-fat diet (P < 0.05). Intragastric administration of lycopene counteracted the change in these parameters (P < 0.05). In this case, the data showed that lycopene in the used dose was better than the fluvastatin intervention. Morphologic analysis revealed that lycopene and fluvastatin markedly reduced the formation of atherosclerotic plaques in the aorta compared with the situation in rabbits on a high-fat diet alone.


Lycopene, like fluvastatin, significantly attenuated atherogenesis in rabbits fed a high-fat diet.

Place, publisher, year, edition, pages
2008. Vol. 24, no 10, 1030-1038 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-53156DOI: 10.1016/j.nut.2008.05.006OAI: diva2:286998
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2010-01-22

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Jiang, Chonghe
In the same journal
Nutrition Journal
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 38 hits
ReferencesLink to record
Permanent link

Direct link