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Clinical Significance of IL-2, IL-10, and TNF-alpha in Prostatic Secretion of Patients With Chronic Prostatitis
The Third Xiangya Hospital, Central South University.
The Third Xiangya Hospital, Central South University.
The Third Xiangya Hospital, Central South University.
Linköping University, Department of Biomedicine and Surgery. Linköping University, Faculty of Health Sciences. (Sivert Lindström)
2010 (English)In: Urology, ISSN 0090-4295, E-ISSN 1527-9995, Vol. 75, no 3, 654-657 p.Article in journal (Refereed) Published
Abstract [en]

Objectives

To explore the clinical significance of interleukin-2 (IL-2), interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-α) in expressed prostatic secretions (EPS) of patients with different types of chronic prostatitis (CP).

Methods

Fifty-seven CP patients and 12 healthy males (controls) were investigated. The CP patients were evaluated through routine examination of urine, EPS, 2 glasses urine culture, and the National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) score and classified by the NIH prostatitis diagnostic criteria. The levels of cytokines TNF-α, IL-10, and IL-2 in the EPS were measured by two-antibody enzyme-linked immunosorbent assay.

Results

CP patients fell into 3 groups: type II (n = 10), type IIIa (n = 26), and type IIIb (n = 21). EPS TNF-α and IL-10 levels were significantly higher in type II and type IIIa than in type IIIb and control groups. The levels of IL-2 were lower than control in all CP groups, but only type II was statistically different from the controls. In the CP patients, the level of TNF-α was positively related to the white blood cell counts (r = .77; P <.01), and the level of IL-10 was positively related to the NIH-CPSI scores (r = .55; P <.01).

Conclusions

Determination of variety expression of TNF-α, IL-10, and IL-2 in the EPS of CP patients may provide a potential indicator for clinical diagnosis classification and an indicator to evaluate the effect of treatment of CP.

Place, publisher, year, edition, pages
2010. Vol. 75, no 3, 654-657 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-53159DOI: 10.1016/j.urology.2009.09.061ISI: 000275814500051OAI: oai:DiVA.org:liu-53159DiVA: diva2:287001
Available from: 2010-01-16 Created: 2010-01-16 Last updated: 2017-12-12

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Jiang, Chonghe

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