Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden
2010 (English)In: Emerging Infectious Diseases, ISSN 1080-6040, E-ISSN 1080-6059, Vol. 16, no 1, 81-87 p.Article in journal (Refereed) Published
Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% Cl 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
Place, publisher, year, edition, pages
2010. Vol. 16, no 1, 81-87 p.
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-53443DOI: 10.3201/eid1601.090633OAI: oai:DiVA.org:liu-53443DiVA: diva2:288845
Johan Nordgren, Per-Eric Lindgren, Andreas Matussek and Lennart Svensson, Norovirus Gastroenteritis Outbreak with a Secretor-independent Susceptibility Pattern, Sweden, 2010, EMERGING INFECTIOUS DISEASES, (16), 1, 81-87.
Licensee: National Center for Infectious Diseases