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Autophagy and aging - The importance of maintaining "clean" cells
Albert Einstein College of Medicine.
University of Pisa.
Linköping University, Department of Medicine and Health Sciences, Pharmacology . Linköping University, Faculty of Health Sciences.
Heidelberg, Germany.
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2005 (English)In: autophagy, Vol. 1, no 3, 131-140 p.Article, review/survey (Refereed) Published
Abstract [en]

A decrease in the turnover of cellular components and the intracellular accumulation of altered macromolecules and organelles are features common to all aged cells. Diminished autophagic activity plays a major role in these age-related manifestations. In this work we review the molecular defects responsible for the malfunctioning of two forms of autophagy, macroautophagy and chaperone-mediated outophagy, in old mammals, and highlight general and cell-type specific consequences of dysfunction of the autophagic system with age. Dietary caloric restriction and antilipolytic agents have been proven to efficiently stimulate autophagy in old rodents. These and other possible experimental restorative efforts are discussed.

Place, publisher, year, edition, pages
2005. Vol. 1, no 3, 131-140 p.
Keyword [en]
antiaging interventions; caloric restriction; inummosenescence; insulin; lipofilscin; lysosomes; mitochondria turnover; protein turnover; replicative senescence
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-53496DOI: 10.4161/auto.1.3.2017OAI: diva2:289831
Available from: 2010-01-25 Created: 2010-01-25 Last updated: 2010-01-25

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Brunk, UlfTerman, Alexei
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Pharmacology Faculty of Health SciencesGeriatric
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