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False-positive breath-alcohol test after a ketogenic diet
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences.
Karolinska Hospital.
2007 (English)In: International Journal of Obesity, ISSN 0307-0565, Vol. 31, no 3, 559-561 p.Article in journal (Refereed) Published
Abstract [en]

A 59-year-old man undergoing weight loss with very low calorie diets (VLCD) attempted to drive a car, which was fitted with an alcohol ignition interlock device, but the vehicle failed to start. Because the man was a teetotaller, he was surprised and upset by this result. VLCD treatment leads to ketonemia with high concentrations of acetone, acetoacetate and beta-hydroxybutyrate in the blood. The interlock device determines alcohol ( ethanol) in breath by electrochemical oxidation, but acetone does not undergo oxidation with this detector. However, under certain circumstances acetone is reduced in the body to isopropanol by hepatic alcohol dehydrogenase (ADH). The ignition interlock device responds to other alcohols ( e. g. methanol, n-propanol and isopropanol), which therefore explains the false-positive result. This side effect of ketogenic diets needs further discussion by authorities when people engaged in safety-sensitive work ( e. g. bus drivers and airline pilots) submit to random breath-alcohol tests.

Place, publisher, year, edition, pages
2007. Vol. 31, no 3, 559-561 p.
Keyword [en]
acetone; alcohol; breath-test; driving; ignition interlocks; VLCD
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-53485DOI: 10.1038/sj.ijo.0803444OAI: diva2:290028
Available from: 2010-01-25 Created: 2010-01-25 Last updated: 2010-01-25

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