Effects of anti-reflux surgery on chronic cough and asthma in patients with gastro-oesophageal reflux disease
2000 (English)In: Respiratory Medicine, ISSN 0954-6111, Vol. 94, no 12, 1166-1170 p.Article in journal (Refereed) Published
This two-group prospective study evaluated the effect of anti-reflux surgery (fundoplication) on 24 patients with severe gastro-oesophageal reflux disease (GORD) and concomitant asthma (n = 13) or chronic cough (n = 11). Twenty-four hour oesophageal pH monitoring and lung function tests (FEV1, FVC) were done before and within 1 year after anti-reflux surgery. A diary was kept by the patient during the 4-week period prior to surgery and during 4-week periods 6 and 12 months postoperatively, with daily monitoring of peak expiratory flow rate, respiratory and reflux symptoms and medication. In non-asthmatic patients, coughing was reduced by 47% and 80% during the day and night, respectively, 12 months after surgery (Pless than0.01). Concomitant hoarseness and expectoration were also significantly reduced (Pless than0.05). No effect on lung function was seen. In patients with asthma, small, non-significant reductions in asthma symptom scores and consumption of rescue medication were seen Twenty-two patients were completely free from their GORD symptoms after surgery. In conclusion, anti-reflux surgery in patients with GORD had a more favourable effect on concomitant cough than concomitant asthma
Place, publisher, year, edition, pages
2000. Vol. 94, no 12, 1166-1170 p.
anti-reflux surgery; aspiration; asthma; cough; gastro-oesophageal reflux
Engineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-53598DOI: 10.1053/rmed.2000.0944OAI: oai:DiVA.org:liu-53598DiVA: diva2:290087