Optical Online Monitoring of Uric Acid Removal during Dialysis
2010 (English)In: BLOOD PURIFICATION, ISSN 0253-5068, Vol. 29, no 1, 69-74 p.Article in journal (Refereed) Published
This study estimates the total removal of uric acid (TRUA) by online UV absorbance measurements in the spent dialysate in two different dialysis centers in Estonia and Sweden. Sixteen dialysis patients were included. All dialysate was collected that gave the reference for TRUA. Two regression models were investigated: one for each patient (UV1) and one for the entire material (UV2). TRUA from the three methods was in the same order but showed a statistically significant difference when the UV2 model was built on data from both centers together. TRUA, (n = 56) was (mean +/- SD, mu mol): 5,854 +/- 1,377 for reference, 6,117 +/- 1,795 for UV1 and 5,762 +/- 1,591 for UV2. Six patients were monitored 1 year after the first study session, using the same models as the previous year, still having a nonsignificant difference. The results show the possibility of estimating TRUA by using UV absorbance. The method appeared to be reliable also in long-term patient monitoring.
Place, publisher, year, edition, pages
2010. Vol. 29, no 1, 69-74 p.
Optical online monitoring, Uric acid removal, Ultraviolet absorbance method
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-53698DOI: 10.1159/000264269OAI: oai:DiVA.org:liu-53698DiVA: diva2:291253