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NK cell activation by KIR-binding antibody 1-7F9 and response to HIV-infected autologous cells in viremic and controller HIV-infected patients
Karolinska Institute.
Soder Sjukhuset, Stockholm, Sweden .
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology . Linköping University, Faculty of Health Sciences.
Karolinska Institute.
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2010 (English)In: CLINICAL IMMUNOLOGY, ISSN 1521-6616, Vol. 134, no 2, 158-168 p.Article in journal (Refereed) Published
Abstract [en]

Natural killer (NK) cells may be protective in HIV infection and are inhibited by killer cell immunoglobulin-like receptors (KIRs) interacting with MHC class I molecules, including HLA-C. Retention of HLA-C despite downregulation of other MHC class I molecules on HIV infected cells might protect infected cells from NK cell recognition in vitro. To assess the role of inhibitory HLA-C ligands in the capacity of NK cells to recognize autologous infected T cells, we measured NK cell degranulation in vitro in viremic patients, controllers with low viremia, and healthy donors. No difference in NK cell response to uninfected compared to HIV-1(IIIB) infected targets was observed. Activation of NK cells was regulated by KIRs, because NK cell degranulation was increased by 1-7F9, a human antibody that binds KIR2DL1/L2/L3 and KIR2DS1/S2, and this effect was most pronounced in KIR haplotype B individuals.

Place, publisher, year, edition, pages
2010. Vol. 134, no 2, 158-168 p.
Keyword [en]
NK cell, HIV, KIR, Viremic controller
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-53696DOI: 10.1016/j.clim.2009.10.001OAI: oai:DiVA.org:liu-53696DiVA: diva2:291255
Available from: 2010-02-01 Created: 2010-02-01 Last updated: 2010-02-01

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Hinkula, Jorma

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