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Ghrelin cell density in the gastrointestinal tracts of animal models of human diabetes.
Linköping University, Department of Molecular and Clinical Medicine, Gastroenterology and Hepatology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Internal Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology UHL.
Linköping University, Department of Clinical and Experimental Medicine, Gastroenterology and Hepatology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Endocrinology and Gastroenterology.
2006 (English)In: Histology and Histopathology, ISSN 0213-3911, E-ISSN 1699-5848, Vol. 21, no 1, 1-5 p.Article in journal (Refereed) Published
Abstract [en]

Ghrelin cell density in the gastrointestinal tract of animal models of human diabetes type 1 and 2 was investigated. The animals used were non-obese diabetic (NOD) mice and obese diabetic mice. Ghrelin cells were detected by immunohistochemistry and quantified by computerized image analysis. Ghrelin-immunoreactive cells were detected in all animals studied. They were abundant in the oxyntic mucosa, patchy and few in the duodenum and rare in the colon. The density of ghrelin-immunoreactive cells decreased in diabetic, pre-diabetic NOD mice and in obese diabetic mice as compared to controls, though not statistically significant. It was concluded that the reduced density of ghrelin-immunoreactive cells in animal models of human diabetes type 1 and 2 might explain the slow gastric emptying and slow intestinal transit found in diabetes gastroenteropathy.

Place, publisher, year, edition, pages
2006. Vol. 21, no 1, 1-5 p.
Keyword [en]
Ghrelin, Diabetes gastroenteropathy, NOD-mice, Obese-diabetic mice
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-53721PubMedID: 16267781OAI: oai:DiVA.org:liu-53721DiVA: diva2:291388
Available from: 2010-02-01 Created: 2010-02-01 Last updated: 2017-12-12

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Spångéus, AnnaEl-Salhy, Magdy

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Spångéus, AnnaEl-Salhy, Magdy
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Gastroenterology and HepatologyFaculty of Health SciencesInternal Medicine Department of Endocrinology and Gastroenterology UHLGastroenterology and Hepatology Department of Endocrinology and Gastroenterology
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Histology and Histopathology
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