Ghrelin cell density in the gastrointestinal tracts of animal models of human diabetes.
2006 (English)In: Histology and Histopathology, ISSN 0213-3911, Vol. 21, no 1, 1-5 p.Article in journal (Refereed) Published
Ghrelin cell density in the gastrointestinal tract of animal models of human diabetes type 1 and 2 was investigated. The animals used were non-obese diabetic (NOD) mice and obese diabetic mice. Ghrelin cells were detected by immunohistochemistry and quantified by computerized image analysis. Ghrelin-immunoreactive cells were detected in all animals studied. They were abundant in the oxyntic mucosa, patchy and few in the duodenum and rare in the colon. The density of ghrelin-immunoreactive cells decreased in diabetic, pre-diabetic NOD mice and in obese diabetic mice as compared to controls, though not statistically significant. It was concluded that the reduced density of ghrelin-immunoreactive cells in animal models of human diabetes type 1 and 2 might explain the slow gastric emptying and slow intestinal transit found in diabetes gastroenteropathy.
Place, publisher, year, edition, pages
2006. Vol. 21, no 1, 1-5 p.
Ghrelin, Diabetes gastroenteropathy, NOD-mice, Obese-diabetic mice
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-53721PubMedID: 16267781OAI: oai:DiVA.org:liu-53721DiVA: diva2:291388