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Expression of VEGF and VEGF Receptors in Childhood Precursor B-cell Acute Lymphoblastic Leukemia Evaluated by Immunohistochemistry
Lund University.
Karolinska University Hospital.
Malmö University Hospital .
Karolinska Institutet.
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2009 (English)In: Journal of pediatric hematology/oncology (Print), ISSN 1077-4114, Vol. 31, no 9, 696-701 p.Article in journal (Refereed) Published
Abstract [en]

Perturbation in the expression and signaling pathways of vascular endothelial growth factor (VEGF) has been linked to pathogenesis of hematologic malignancies. We investigated the expression and clinical importance of VEGF and two of its receptors, VEGFR-1 and VEGFR-2, in childhood precursor B-cell acute lymphoblastic leukemia (pre-B ALL) by using immunohistochemistry. These angiogenic proteins were expressed in the majority of leukemic bone marrow samples. Notably, pre-B ALL patients had significantly increased expression of VEGFR-1 compared with no expression in the nonmalignant group, indicating a link between VEGFR-1 protein expression and pre-B ALL. These novel findings suggest that VEGFR-1 may have clinical importance in childhood pre-B ALL.

Place, publisher, year, edition, pages
2009. Vol. 31, no 9, 696-701 p.
Keyword [en]
VEGF; VEGFR-1; VEGFR-2; childhood pre-B ALL; immunohistochemistry
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-53853DOI: 10.1097/MPH.0b013e3181b258dfISI: 000269701800018OAI: diva2:292424
Available from: 2010-02-06 Created: 2010-02-06 Last updated: 2010-03-26

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Gustafsson, Bertil
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Department of Clinical and Experimental MedicineFaculty of Health SciencesDepartment of Clinical Pathology and Clinical Genetics
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Journal of pediatric hematology/oncology (Print)
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ReferencesLink to record
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