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The first case history of multiple sclerosis: Augustus dEst, (1794-1848)
Linköping University, Department of Clinical and Experimental Medicine, Neurology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Neurology. Östergötlands Läns Landsting, Local Health Care Services in the West of Östergötland, Department of Medical Specialist.
University Ferrara.
Karolinska Institute.
University Ferrara.
2010 (English)In: NEUROLOGICAL SCIENCES, ISSN 1590-1874, Vol. 31, no 1, 29-33 p.Article in journal (Refereed) Published
Abstract [en]

The personal diary of Sir Augustus dEst,, born 1794 grandson of King George III of England, reveals a medical history strongly suggesting that Augustus suffered from multiple sclerosis (MS). It could well be the first record of a person having this disease. Charcot coined the term scl,rose en plaques 20 years after the death of this patient in 1848. The onset of this mans MS seems to have been in 1822 with bilateral optic neuritis, the disease gradually developing in the classic manner with bouts derived from different loci in the central nervous system and eventually a secondary progressive form with paraparesis, sphincter incontinence, urinary problems and impotence. In 1941, Firth highlighted the case of Augustus dEst, and later wrote a description of the pathology including a discussion on the aetiology of MS. No previous medical records have given such a characteristic picture of MS as this.

Place, publisher, year, edition, pages
2010. Vol. 31, no 1, 29-33 p.
Keyword [en]
Multiple sclerosis, Medical history, Case report
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-53931DOI: 10.1007/s10072-009-0161-4ISI: 000273980300005OAI: diva2:293556
Available from: 2010-02-12 Created: 2010-02-12 Last updated: 2012-04-03

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Landtblom, Anne-Marie
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NeurologyFaculty of Health SciencesDepartment of NeurologyDepartment of Medical Specialist
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