Evaluation of a Fiber-Optic Based Pulsed Laser System for Fluorescence Spectroscopy
2008 (English)Conference paper (Refereed)
A fiber optic based continous wave laser setup has been developed to record the 5-aminolevulinic (5-ALA) induced Protoporfyrin IX (PpIX) fluorescence signals from cerebral gliomas. To reduce the energy delivered to the tissue as well as suppression of the ambient lamp artifact from the recorded spectra, a pulsed laser setup has been developed and evaluated. This setup has been calibrated and first evaluations were performed on the 5-ALA treated skin showing PpIX fluorescence peaks from the ALA treated skin at 635 and 704 nm wavelengths. The system controls laser pulses through a computer interface and labview software package. Pulses as short as 50 ms over a period time of 500 ms are generated and optimally detected. The results from primary measurements on skin show an effective suppression of room fluorescent lamp artifact from the recorded spectra.
Place, publisher, year, edition, pages
Springer Berlin Heidelberg , 2008. Vol. 20, no 5, 4 p.363-366 p.
, IFMBE Proceedings, ISSN 1680-0737 ; 20
Fluorescence spectroscopy, Pulsed laser modulation, 5-aminolevulinic acid induced fluorescence, Glioma resection, Intraoperative optical guide
National CategoryEngineering and Technology
IdentifiersURN: urn:nbn:se:liu:diva-53945DOI: 10.1007/978-3-540-69367-3_97ISBN: 978-3-540-69366-6 (print)ISBN: 978-3-540-69367-3 (online)OAI: oai:DiVA.org:liu-53945DiVA: diva2:293887
14th Nordic-Baltic Conference on Biomedical Engineering and Medical Physics IFMBE Proceedings
FunderVinnovaSwedish Foundation for Strategic Research Swedish Research Council