Use of hormonal contraceptives in relation to antidepressant therapy: A nationwide population-based study
2010 (English)In: European journal of contraception & reproductive health care, ISSN 1362-5187, E-ISSN 1473-0782, Vol. 15, no 1, 41-47 p.Article in journal (Refereed) Published
OBJECTIVES: The relation between the use of different hormonal contraceptives and antidepressant therapy was investigated. METHODS: In a nationwide cross-sectional study among all women in Sweden aged 16-31, drug expenditure data on hormonal contraceptives and antidepressants were obtained from the Swedish Prescribed Drug Register. Odds ratios (ORs) for antidepressant use were calculated by logistic regression for progestin-only users versus non-users as well as for combined hormonal contraceptive (CHC) users versus non-users. RESULTS: In the study population (N = 917,993), 58.9% were hormonal contraceptive users, and 8.5% were antidepressant users. The age-pattern for antidepressant ORs differed between the two types of users of contraceptives; progestin-only users had significant ORs above 1 in all age groups whereas among CHC users the OR was above 1 solely in those aged 16-19. The largest difference between types of users was seen in the age group 16-19 in which women resorting to a progestin-only contraceptive had a 67% (95% confidence interval: 57- 78%) higher antidepressant use than women treated with a CHC. CONCLUSION: Progestin-only contraceptive users resorted to antidepressants more than users of CHCs. This phenomenon is particularly pronounced among teenagers. Therefore, special attention should be given to young women's mental history when prescribing hormonal contraceptives and vice versa: the contraceptive history should be taken into account when prescribing antidepressants.
Place, publisher, year, edition, pages
2010. Vol. 15, no 1, 41-47 p.
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-53952DOI: 10.3109/13625181003587004ISI: 000274856300007PubMedID: 20136568OAI: oai:DiVA.org:liu-53952DiVA: diva2:293947
This is an electronic version of an article published in: Ann-Britt Wiréhn, Anniqa Foldemo, Ann Josefsson and Malou Lindberg, Use of hormonal contraceptives in relation to antidepressant therapy: A nationwide population-based study., 2010, European journal of contraception & reproductive health care, (15), 1, 41-47. European journal of contraception & reproductive health care is available online at informaworldTM: http://dx.doi.org/10.3109/13625181003587004 Copyright: Taylor & Francis http://www.tandf.co.uk/journals/default.asp2010-02-152010-02-152014-01-13