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K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
Linköping University, Department of Biomedicine and Surgery, Division of dermatology and venereology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Surgery and Oncology, Department of Oncology UHL.
Linköping University, Department of Biomedicine and Surgery, Oncology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Biomedicine and Surgery, Cell biology. Linköping University, Faculty of Health Sciences.
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1998 (English)In: European Journal of Cancer, ISSN 0959-8049, E-ISSN 1879-0852, Vol. 34, no 13, 2053-2057 p.Article in journal (Refereed) Published
Abstract [en]

The K-ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa (n = 106), transitional mucosa (n = 69) and tumours (n = 149) from 149 patients with colorectal adenocarcinomas. K-ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, but not in the normal mucosa. Further, mutation rates were increased in younger patients (P = 0.001) and in mucinous carcinomas (50%) compared with well differentiated (17%), moderately differentiated (26%) or poorly differentiated (24%) tumours. Our findings indicate that mucinous carcinoma may represent a distinct genetic entity.

Place, publisher, year, edition, pages
1998. Vol. 34, no 13, 2053-2057 p.
Keyword [en]
K-ras; transitional mucosa; mucinous carcinomas; colorectal cancer; allele-specific PCR
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-53953DOI: 10.1016/S0959-8049(98)00283-4PubMedID: 10070310OAI: oai:DiVA.org:liu-53953DiVA: diva2:293952
Available from: 2010-02-15 Created: 2010-02-15 Last updated: 2017-12-12

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Zhang, HongNordenskjöld, BoDufmats, MonikaSöderkvist, PeterSun, Xiao-Feng

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Zhang, HongNordenskjöld, BoDufmats, MonikaSöderkvist, PeterSun, Xiao-Feng
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Division of dermatology and venereologyFaculty of Health SciencesOncologyDepartment of Oncology UHLCell biology
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European Journal of Cancer
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