K-ras mutations in colorectal adenocarcinomas and neighbouring transitional mucosa.
1998 (English)In: European Journal of Cancer, ISSN 0959-8049, Vol. 34, no 13, 2053-2057 p.Article in journal (Refereed) Published
The K-ras gene in codons 12 and 13 was investigated using allele-specific polymerase chain reaction in matched normal mucosa (n = 106), transitional mucosa (n = 69) and tumours (n = 149) from 149 patients with colorectal adenocarcinomas. K-ras mutations in codon 12 were detected in 41/149 (28%) of tumours and 4/69 (6%) of transitional mucosa samples, but not in the normal mucosa. Further, mutation rates were increased in younger patients (P = 0.001) and in mucinous carcinomas (50%) compared with well differentiated (17%), moderately differentiated (26%) or poorly differentiated (24%) tumours. Our findings indicate that mucinous carcinoma may represent a distinct genetic entity.
Place, publisher, year, edition, pages
1998. Vol. 34, no 13, 2053-2057 p.
K-ras; transitional mucosa; mucinous carcinomas; colorectal cancer; allele-specific PCR
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-53953DOI: 10.1016/S0959-8049(98)00283-4PubMedID: 10070310OAI: oai:DiVA.org:liu-53953DiVA: diva2:293952