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To treat snoring with nasal steroids - effects on more than one level?
Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
Östergötlands Läns Landsting, Anaesthesiology and Surgical Centre, Department of Anaesthesiology and Intensive Care VHN. (Landstinget i Östergötland)
Linköping University, Department of Clinical and Experimental Medicine, Oto-Rhiono-Laryngology and Head & Neck Surgery . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Reconstruction Centre, Department of ENT - Head and Neck Surgery UHL.
2010 (English)In: ACTA OTO-LARYNGOLOGICA, ISSN 0001-6489, Vol. 130, no 1, 124-131 p.Article in journal (Refereed) Published
Abstract [en]

Conclusion. An inflammatory swelling in the uvula and nose due to vibration might be a contributing factor in snoring. The presence of corticosteroid receptors in the uvula indicates the possibility for treatment with local steroids. Use of mometasone furoate (MF) for 3 months reduced snoring and related symptoms in some patients. Objective. To investigate the effect of a nasal steroid, MF, on snoring and related discomfort. Subjects and methods. In the first part of the study, uvular and nasal biopsies from six patients with social snoring were examined using immunohistochemistry to evaluate whether corticosteroid receptors were present. Then 100 snoring patients were invited to participate in the second part of the study. In all, 72 men and 22 women with a mean age of 47 years and BMI 27 answered a questionnaire about symptoms, had ENT status assessed and reported sleep and related variables for a 7 day period. After randomization to placebo or MF, they used a nasal spray for 3 months at a dosage of 200 mu g. Thereafter the procedure was repeated. Results. Corticosteroid receptors were present in the mucous membranes and around the blood vessels in all uvulas examined. A total of 84 patients were evaluated. No decrease in mean snoring score was seen. Daytime sleepiness showed a slight improvement in the MF group and partners were less disturbed. Minor side effects were equal for both groups.

Place, publisher, year, edition, pages
2010. Vol. 130, no 1, 124-131 p.
Keyword [en]
Snoring, nasal steroids, corticosteroid receptors, uvular histology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-54169DOI: 10.3109/00016480902934211ISI: 000274416300021OAI: oai:DiVA.org:liu-54169DiVA: diva2:300364
Note
This is an electronic version of an article published in: Elisabeth Hultcrantz, Lena Harder, Eva-Lena Zetterlund and Karin Roberg, To treat snoring with nasal steroids - effects on more than one level?, 2010, ACTA OTO-LARYNGOLOGICA, (130), 1, 124-131. ACTA OTO-LARYNGOLOGICA is available online at informaworldTM: http://dx.doi.org/10.3109/00016480902934211 Copyright: Taylor & Francis http://www.tandf.co.uk/journals/default.asp Available from: 2010-02-26 Created: 2010-02-26 Last updated: 2010-03-23

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