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Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress
Karolinska Institute.
Karolinska Institute.
Karolinska Institute.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Chemistry. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Chemistry.
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2010 (English)In: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, ISSN 0892-3973, Vol. 32, no 1, 147-152 p.Article in journal (Refereed) Published
Abstract [en]

Material and methods: We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized). Results: There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis. Conclusion: Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.

Place, publisher, year, edition, pages
2010. Vol. 32, no 1, 147-152 p.
Keyword [en]
Stress, atopic eczema, innervation, PGP 9.5, GAP-43
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-54398DOI: 10.3109/08923970903219633ISI: 000274909100020OAI: diva2:303532
Available from: 2010-03-12 Created: 2010-03-12 Last updated: 2010-03-12

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Theodorsson, Elvar
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