Decreased innervation of eczematous skin in NC/Nga atopic mice during chronic mild stress
2010 (English)In: IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, ISSN 0892-3973, Vol. 32, no 1, 147-152 p.Article in journal (Refereed) Published
Material and methods: We used three groups of mice, stressed control (SC, stressed but not immunized with a mite antigen), non-stressed eczematous (NSE, not stressed but immunized) and stressed eczematous (SE, stressed and immunized). Results: There was a decrease of protein gene product (PGP) 9.5 positive nerve fibers in SE compared to SC mice, in both epidermis and dermis, also in SE compared to NSE mice. Also a decrease in growth associated protein (GAP)-43 positive nerve fibers was seen in SE compared to SC, in both epidermis and dermis. Conclusion: Chronic mild stress in atopic mice leads to decreased innervation in eczematous lesions.
Place, publisher, year, edition, pages
2010. Vol. 32, no 1, 147-152 p.
Stress, atopic eczema, innervation, PGP 9.5, GAP-43
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-54398DOI: 10.3109/08923970903219633ISI: 000274909100020OAI: oai:DiVA.org:liu-54398DiVA: diva2:303532