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Mapping of hormones and cortisol responses in patients after Lyme neuroborreliosis
Linköping University, Department of Clinical and Experimental Medicine, Infectious Diseases. Linköping University, Faculty of Health Sciences.
Kalmar County Hospital.
Linköping University, Department of Clinical and Experimental Medicine, Clinical Immunology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Diagnostics, Department of Clinical Immunology and Transfusion Medicine.
NAL, Trollhattan, Sweden .
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2010 (English)In: BMC INFECTIOUS DISEASES, ISSN 1471-2334, Vol. 10, no 20Article in journal (Refereed) Published
Abstract [en]

Background: Persistent symptoms after treatment for neuroborreliosis are common for reasons mainly unknown. These symptoms are often unspecific and could be caused by dysfunctions in endocrine systems, an issue that has not been previously addressed systematically. We therefore mapped hormone levels in patients with previous confirmed Lyme neuroborreliosis of different outcomes and compared them with a healthy control group. Methods: Twenty patients of a retrospective cohort of patients treated for definite Lyme neuroborreliosis were recruited 2.3 to 3.7 years (median 2.7) after diagnosis, together with 23 healthy controls. Lyme neuroborreliosis patients were stratified into two groups according to a symptom/sign score. All participants underwent anthropometric and physiological investigation as well as an extensive biochemical endocrine investigation including a short high-dose adrenocorticotropic hormone stimulation (Synacthen (R)) test. In addition to hormonal status, we also examined electrolytes, 25-hydroxy-vitamin D and interleukin-6. Results: Eight patients (40%) had pronounced symptoms 2-3 years after treatment. This group had a higher cortisol response to synacthen as compared with both controls and the Lyme neuroborreliosis patients without remaining symptoms (p andlt; 0.001 for both comparisons). No other significant differences in the various baseline biochemical parameters, anthropometric or physiological data could be detected across groups. Conclusions: Apart from a positive association between the occurrence of long-lasting complaints after Lyme neuroborreliosis and cortisol response to synacthen, no corticotropic insufficiency or other serious hormonal dysfunction was found to be associated with remaining symptoms after treatment for Lyme neuroborreliosis.

Place, publisher, year, edition, pages
2010. Vol. 10, no 20
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-54510DOI: 10.1186/1471-2334-10-20ISI: 000275317700001OAI: diva2:304587
Original Publication: Ivar Tjernberg, Martin Carlsson, Jan Ernerudh, Ingvar Eliasson and Pia Forsberg, Mapping of hormones and cortisol responses in patients after Lyme neuroborreliosis, 2010, BMC INFECTIOUS DISEASES, (10), 20. Licensee: BioMed Central Available from: 2010-03-19 Created: 2010-03-19 Last updated: 2011-02-04

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Tjernberg, IvarErnerudh, JanForsberg, Pia
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Infectious DiseasesFaculty of Health SciencesClinical ImmunologyDepartment of Clinical Immunology and Transfusion MedicineDepartment of Infectious Diseases in Östergötland
Medical and Health Sciences

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