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Toxicology of Autoimmune Diseases
Scripps Research Institute.
Linköping University, Department of Clinical and Experimental Medicine, Molecular and Immunological Pathology. Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Laboratory Medicine, Department of Clinical Pathology and Clinical Genetics.
Scripps Research Institute.
2010 (English)In: CHEMICAL RESEARCH IN TOXICOLOGY, ISSN 0893-228X, Vol. 23, no 3, 455-466 p.Article in journal (Refereed) Published
Abstract [en]

Susceptibility to most autoimmune diseases is dependent on polygenic inheritance, environmental factors, and poorly defined stochastic events. One of the significant challenges facing autoimmune disease research is in identifying the specific events that trigger loss of tolerance and autoimmunity. Although many intrinsic factors, including age, sex, and genetics, contribute to autoimmunity, extrinsic factors such as drugs, chemicals, microbes, or other environmental factors can also act as important initiators. This review explores how certain extrinsic factors, namely, drugs and chemicals, can promote the development of autoimmunity, focusing oil a few better characterized agents that, in most instances, have been shown to produce autoimmune manifestations in human populations. Mechanisms of autoimmune disease induction are discussed in terms of research obtained using specific animal models. Although a number of different pathways have been delineated for drug/chemical-induced autoimmunity, some similarities do exist, and a working model is proposed.

Place, publisher, year, edition, pages
2010. Vol. 23, no 3, 455-466 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-54616DOI: 10.1021/tx9003787ISI: 000275411700006OAI: diva2:305987
Available from: 2010-03-26 Created: 2010-03-26 Last updated: 2014-10-03

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Hultman, Per
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Molecular and Immunological PathologyFaculty of Health SciencesDepartment of Clinical Pathology and Clinical Genetics
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ReferencesLink to record
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