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Methicillin-resistant Staphylococcus aureus (MRSA) in municipal wastewater: an uncharted threat?
Linköping University, Department of Clinical and Experimental Medicine, Medical Microbiology . Linköping University, Faculty of Health Sciences.
Unilabs, Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine. Linköping University, Faculty of Health Sciences.
County Hospital Ryhov.
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2010 (English)In: JOURNAL OF APPLIED MICROBIOLOGY, ISSN 1364-5072, Vol. 108, no 4, 1244-1251 p.Article in journal (Refereed) Published
Abstract [en]

Aims: (i) To cultivate methicillin-resistant Staphylococcus aureus (MRSA) from a full-scale wastewater treatment plant (WWTP), (ii) To characterize the indigenous MRSA-flora, (iii) To investigate how the treatment process affects clonal distribution and (iv) To examine the genetic relation between MRSA from wastewater and clinical MRSA. Methods: Wastewater samples were collected during 2 months at four key sites in the WWTP. MRSA isolates were characterized using spa typing, antibiograms, SSCmec typing and detection of Panton-Valentine leukocidin (PVL). Conclusions: MRSA could be isolated on all sampling occasions, but only from inlet and activated sludge. The number of isolates and diversity of MRSA were reduced by the treatment process, but there are indications that the process was selected for strains with more extensive antibiotic resistance and PVL+ strains. The wastewater MRSA-flora had a close genetic relationship to clinical isolates, most likely reflecting carriage in the community. Significance and Impact of the Study: This study shows that MRSA survives in wastewater and that the WWTP may be a potential reservoir for MRSA.

Place, publisher, year, edition, pages
2010. Vol. 108, no 4, 1244-1251 p.
Keyword [en]
antibiotic resistance, methicillin-resistant Staphylococcus aureus, Panton-Valentine leukocidin, SCCmec, spa typing, Staphylococcus aureus, wastewater, wastewater treatment plant
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-54611DOI: 10.1111/j.1365-2672.2009.04515.xISI: 000275465700014OAI: diva2:305990
Available from: 2010-03-26 Created: 2010-03-26 Last updated: 2010-03-26

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Borjesson, StefanMelin, SaraLindgren, Per-Eric
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Medical Microbiology Faculty of Health SciencesDepartment of Clinical and Experimental Medicine
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