The Immune Risk Phenotype and IL-6 among Nonagenarians and Associations with Morbidity and Mortality: Findings from the Swedish NONA Immune Longitudinal Study
(English)Manuscript (preprint) (Other academic)
In this NONA immune longitudinal study, we examine 4-year mortality in relation to a set of laboratory parameters, morbidity and cause of death in a population-based sample of oldest-old individuals (n=138). Four groups were constructed based on levels for the CD4/CD8 ratio (above or below one = IRP, immune risk phenotype group) and levels for IL-6 (below or above the median 3.15 pg/mL). 4-year mortality was higher in the “IRP” group (73 %), the “IL-6” group (64 %), and the “Double risk group” (82 %) compared with the “No risk” group (29 %; p-values between .005 and .000). Cognitive dysfunction and dementia were more common in the two groups with elevated IL-6 levels (p-values between .014 and .001), whereas cardiovascular disease tended (p = .081) to be associated with both “IRP” and “IL-6” groups. The most common cause of death was related to cardio- and cerebrovascular disease (59 %,), followed by infection in 15 % of the cases and cancer in 7 %. Despite their strong associations with 4-year mortality, neither IRP nor IL-6 could be linked to any specific cause of death, possibly because both IRP and IL-6 are multi-factorial risk factors, being associated with several different diseases and mechanisms which cause death.
survival, mortality, CMV, cytomegalovirus, CD8, T-cells, inflammation, immuner risk phenotype, IRP, cause of death
Immunology in the medical area
IdentifiersURN: urn:nbn:se:liu:diva-54674OAI: oai:DiVA.org:liu-54674DiVA: diva2:306855