liu.seSearch for publications in DiVA
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis
Linköping University, Department of Clinical and Experimental Medicine, Rheumatology . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre for Medicine, Department of Rheumatology in Östergötland.
Umeå University.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Linköping University, Department of Clinical and Experimental Medicine, Cell Biology. Linköping University, Faculty of Health Sciences.
Show others and affiliations
2010 (English)In: ANNALS OF THE RHEUMATIC DISEASES, ISSN 0003-4967, Vol. 69, no 4, 723-726 p.Article in journal (Refereed) Published
Abstract [en]

Objectives CARD8 and NLRP3 are constituents of the inflammasome which regulates interleukin 1 beta production. The influence of polymorphisms in CARD8 and NLRP3 on rheumatoid arthritis (RA) susceptibility and severity were evaluated. Methods CARD8 p.C10X and NLRP3 p.Q705K genotypes were assessed in andgt;500 controls and patients with early RA from northern Sweden. The patients were monitored regularly over a 2-year period. The 28-joint disease activity score (DAS28) and its separate components were compared across genotypes. Results Patients with one or more variant alleles in CARD8 (CARD8-X) had increased DAS28, tender joint count and erythrocyte sedimentation rate during the 2-year follow-up period despite receiving disease-modifying antirheumatic drugs to a greater extent. CARD8-X was significantly over-represented among patients who received anti-tumour necrosis factor therapy during the first 2 years. CARD8 and NLRP3 genotypes did not influence radiological joint damage and were not associated with an increased susceptibility. Conclusions Carriage of CARD8-X is associated with a worse disease course in early RA.

Place, publisher, year, edition, pages
2010. Vol. 69, no 4, 723-726 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-54719DOI: 10.1136/ard.2008.106989ISI: 000275723800019OAI: oai:DiVA.org:liu-54719DiVA: diva2:308388
Note
Original Publication: Alf Kastbom, Martin Johansson, Deepti Verma, Peter Söderkvist and Solbritt Rantapaa-Dahlqvist, CARD8 p.C10X polymorphism is associated with inflammatory activity in early rheumatoid arthritis, 2010, ANNALS OF THE RHEUMATIC DISEASES, (69), 4, 723-726. http://dx.doi.org/10.1136/ard.2008.106989 Copyright: BMJ Publishing Group http://group.bmj.com/ Available from: 2010-04-06 Created: 2010-04-06 Last updated: 2010-08-17

Open Access in DiVA

fulltext(237 kB)383 downloads
File information
File name FULLTEXT01.pdfFile size 237 kBChecksum SHA-512
56272ea60ea5f1d2285b8803cfddd1a94b87e04932629424146b6bbc4a8459a012e81c3ef67a1bb06457dfb0e10f2b90b3b87a04fcd8d09816ec18f42578de75
Type fulltextMimetype application/pdf

Other links

Publisher's full text

Authority records BETA

Kastbom, AlfVerma, DeeptiSöderkvist, Peter

Search in DiVA

By author/editor
Kastbom, AlfVerma, DeeptiSöderkvist, Peter
By organisation
Rheumatology Faculty of Health SciencesDepartment of Rheumatology in ÖstergötlandCell Biology
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
Total: 383 downloads
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

doi
urn-nbn

Altmetric score

doi
urn-nbn
Total: 96 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • oxford
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf