liu.seSearch for publications in DiVA
Change search
ReferencesLink to record
Permanent link

Direct link
TRAF6 as the Key Adaptor of TLR4 Signaling Pathway Is Involved in Acute Pancreatitis
Sichuan University.
Sichuan University.
Sichuan University.
Sichuan University.
Show others and affiliations
2010 (English)In: PANCREAS, ISSN 0885-3177, Vol. 39, no 3, 359-366 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: To study the potential role of tumor necrosis factor receptor-associated factor 6 (TRAF6) as the key adaptor of the toll-like receptor 4 (TLR4) signaling pathway in acute pancreatitis (AP) in mice. Methods: Acute pancreatitis was induced by 7 intraperitoneal injections of cerulein in TLR4-deficient (TLR4-Def) and TLR4 wild-type (TLR4-WT) mice. Inflammatory severity was scored and evaluated based on pathological study. TRAF6 expression was determined by reverse transcriptase polymerase chain reaction, Western blot, and immunohistochemistry. Results: Acute pancreatitis was successfully induced in both mice strains, but the inflammatory progression was different. In TLR4-Def mice, pancreatic inflammation was blunt and mild first, then became increasingly intensive and peaked at the later stage, whereas in the TLR4-WT mice, the response was fast initiated and peaked at the early stage of AP, then alleviated gradually. TRAF6 expression in TLR4-Def mice was significantly higher than that in the TLR4-WT mice. Immunohistochemistry located TRAF6 expressed mainly in the pancreatic acinar cells. Conclusions: The TLR4-TRAF6 signaling pathway is critically involved in AP. Other signaling pathways beyond TLR4 may participate in the pancreatic inflammatory process via TRAF6. As a convergence point of the TLR4-dependent and the TLR4-independent signaling pathways, TRAF6 plays an important role in AP.

Place, publisher, year, edition, pages
2010. Vol. 39, no 3, 359-366 p.
Keyword [en]
acute pancreatitis, toll-like receptor 4, tumor necrosis factor receptor-associated factor 6
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-54771DOI: 10.1097/MPA.0b013e3181bb9073ISI: 000275955500011OAI: diva2:309850
Available from: 2010-04-09 Created: 2010-04-09 Last updated: 2010-04-09

Open Access in DiVA

No full text

Other links

Publisher's full text

Search in DiVA

By author/editor
Sun, Xiao-Feng
By organisation
Oncology Faculty of Health SciencesDepartment of Oncology UHL
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar
The number of downloads is the sum of all downloads of full texts. It may include eg previous versions that are now no longer available

Altmetric score

Total: 54 hits
ReferencesLink to record
Permanent link

Direct link