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Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes
Karolinska Institute.
Karolinska University.
Karolinska Institute.
Karolinska University.
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2010 (English)In: VACCINE, ISSN 0264-410X, Vol. 28, no 9, 2080-2087 p.Article in journal (Refereed) Published
Abstract [en]

Delivery of DNA encoding foreign antigens into mammalian cells can induce adaptive immune responses. There are currently many DNA-based vaccines in clinical trials against infectious diseases and cancer but there is a lack of adjuvants for improvement of responses to DNA-based vaccines. Here, we show augmented systemic and mucosa-associated B cell responses after immunization with a cocktail of seven different plasmids (3 env, 2 gag, 1 rev, 1 RT) combined with mitogen activated apoptotic syngeneic lymphocytes in mice. In addition we show that apoptotic cells can function as adjuvant for induction of cellular immune responses in a magnitude comparable to the cytokine adjuvant GM-CSF in mice. These data suggest that activated apoptotic lymphocytes can act independent as adjuvants to improve antigen-specific DNA vaccines.

Place, publisher, year, edition, pages
Elsevier Science B.V. , 2010. Vol. 28, no 9, 2080-2087 p.
Keyword [en]
HIV-1, Adjuvant, Apoptosis
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-54765DOI: 10.1016/j.vaccine.2009.12.040ISI: 000275991300010OAI: oai:DiVA.org:liu-54765DiVA: diva2:309863
Available from: 2010-04-09 Created: 2010-04-09 Last updated: 2010-04-09

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Hinkula, Jorma

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