Neuroprotective Effect of Genistein in 6-Hydroxydopamine Hemi-parkinsonian Rat Model
2008 (English)In: International Journal of Psychophysiology, ISSN 0167-8760, E-ISSN 1872-7697, Vol. 69, no 3, 315- p.Article in journal (Refereed) Published
A large body of experimental evidence supports a role for oxidative stress as a mediator of nerve cell death in Parkinson-s disease (PD). Phytoestrogens such as genistein have been reported to prevent neuronal degeneration caused by increased oxidative burden, therefore, this study examined whether genistein administration at a high dose would attenuate behavioral and structural abnormalities in an experimental model of PD in rat. For this purpose, unilateral intrastriatal 6-hydroxydopamine (6-OHDA, 12.5 μg/5 μL of saline-ascorbate)- lesioned rats were intraperitoneally pretreated with a single and high dose of genistein (10 mg/kg) 1 h before surgery. Apomorphine-induced rotations and the number of Nissl-stained neurons in the substantia nigra pars compacta (SNC) were counted after 2 weeks. Genistein administration could attenuate the rotational behavior in lesioned rats and protect the neurons of SNC against 6-OHDA toxicity. Genistein administration has a protective effect against 6-OHDA toxicity.
Place, publisher, year, edition, pages
2008. Vol. 69, no 3, 315- p.
genistein • Parkinson's disease • 6-hydroxydopamine • rotation • rat
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-54798DOI: 10.1016/j.ijpsycho.2008.05.568OAI: oai:DiVA.org:liu-54798DiVA: diva2:310125
Abstracts of the 14th World Congress of Psychophysiology - The Olympics of the Brain - of the International Organization of Psychophysiology (I.O.P) Associated with the United Nations 2009-10-102009-10-102012-05-07