Monoamines, BDNF, IL-6 and corticosterone in CSF in patients with Parkinsons disease and major depression
2010 (English)In: JOURNAL OF NEUROLOGY, ISSN 0340-5354, Vol. 257, no 4, 524-532 p.Article in journal (Refereed) Published
The biochemical basis of major depression (MD) in Parkinsons disease (PD) is largely unknown. To increase our understanding of MD in PD patients, the levels of monoamine metabolites (HVA, 5-HIAA and MHPG), BDNF, orexin-A, IL-6 and corticosterone were examined in cerebrospinal fluid. The analyses were performed in MD patients with (n = 11) and without (n = 12) PD at baseline and after 12 weeks of treatment with the antidepressant citalopram, and in patients with solely PD (n = 14) at baseline and after 12 weeks. The major findings were that PD patients with MD had significantly lower baseline levels of MHPG, corticosterone and IL-6 when compared to patients with solely MD. In response to citalopram treatment, patients with solely MD exhibited an expected decrease in 5-HIAA and MHPG levels which was not found in PD patients with MD. Moreover, the levels of BDNF and IL-6 were lower in PD patients with MD compared with patients with solely MD after treatment with citalopram. Thus, the biochemical basis and the response to citalopram differ between PD patients with MD and patients with solely MD.
Place, publisher, year, edition, pages
Springer Science Business Media , 2010. Vol. 257, no 4, 524-532 p.
Parkinsons disease, Major depression, Cerebrospinal fluid, Biomarker, HVA, 5-HIAA, MHPG, BDNF, Corticosterone, IL-6, Citalopram, SSRI
Medical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-54857DOI: 10.1007/s00415-009-5353-6ISI: 000276254900004OAI: oai:DiVA.org:liu-54857DiVA: diva2:310856