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Non-invasive monitoring of haemodynamic changes in haemodialysis patients using photoplethysmography (PPG)
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
Department of Renal Medicine, Huddinge University Hospital, Sweden.
Linköping University, Department of Biomedical Engineering. Linköping University, The Institute of Technology.
2002 (English)Manuscript (preprint) (Other academic)
Abstract [en]

Presently there is no simple non-invasive method to monitor haemodynamic changes during haemodialysis but such a method is highly needed. This study aims at investigating the possibility to monitor such changes during a single haemodialysis session using a photoplethysmography method (PPG). This non-invasive method illuminates a proportion of the patients skin and the received PPG-signal reflects local blood flow. The haemodialysis sessions were performed as in normal routine with more frequently performed blood pressure measurements by an oscillometric method or with continuous intra arterial blood pressure measurements. The obtained PPG-signals are linked to the blood pressure changes and are affected by the ultrafiltration rate and drugs administrated during the session. The relation between the blood pressure changes and the changes in the different PPG components seems however to be complex and need to be investigate further. The PPG-method shows promises, which is emphasised by the strong need of a non-invasive monitoring method.

Place, publisher, year, edition, pages
2002.
Keyword [en]
haemodialysis, photoplethysmography, blood flow, haemodynamics
National Category
Engineering and Technology
Identifiers
URN: urn:nbn:se:liu:diva-54997OAI: oai:DiVA.org:liu-54997DiVA: diva2:313671
Available from: 2010-04-27 Created: 2010-04-27 Last updated: 2012-12-21
In thesis
1. Monitoring principles for haemodialysis
Open this publication in new window or tab >>Monitoring principles for haemodialysis
2002 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

This thesis deals with non-invasive monitoring techniques for haemodialysis. Three applications in particular have been investigated: Blood pressure measurements in the extra corporal circuit, the relationship between UV measurements and dialysate urea concentration and photoplethysmography (PPG) in haemodialysis patients.

A non-invasive pressure sensor as an integrated part of the extracorporeal tube circuit was developed using modified cross-section tube geometry. The expansions of the modified tubes with different cross-sectional geometries were studied upon application of pressure, both experimentally and numerically, using the finite element method. Factorial design was used to study the relationship between pressure in the tube and force needed to restore the expanding tube to its original dimension. This investigation was performed for different tube cross-sectional geometries. A pressure sensor was designed, based on the previously obtained findings. The evaluation of the pressure sensor showed that the output corresponded well to applied pressure (R2=0.99).

An UV-method for studying waste products in the dialysate has recently been developed by our research group. In the present study, it was investigated how the relationship between UV-absorption and dialysate urea concentration was affected by the treatment settings, patient anamnesis and prescribed pharmaceuticals. A mathematical model was proposed which includes these effects. Multiregression analysis indicated the possibility of performing individual estimates of urea concentration from UV-absorption.

During haemodialysis, the patient's cardiovascular system is affected when excess fluid is extracted, which may result in blood pressure fluctuations. In the present study, a novel PPG method for monitoring haemodynamic changes during dialysis was investigated. The performed study indicates that PPG measurements relate to haemodynamic changes and may thus be useful in the patient monitoring. However, the relationship is complex and needs further studies.

Place, publisher, year, edition, pages
Linköping: Linköpings universitet, 2002. 45 p.
Series
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 737
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:liu:diva-24563 (URN)6728 (Local ID)91-7373-270-2 (ISBN)6728 (Archive number)6728 (OAI)
Public defence
2002-05-21, Aulan, Administrationshuset, Universitetssjukhuset, Linköping, 10:15 (Swedish)
Opponent
Available from: 2009-10-07 Created: 2009-10-07 Last updated: 2012-12-21

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Andersson, RogerLindberg, Lars-Göran

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