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Teriparatide improves early callus formation in distal radial fractures
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
Linköping University, Department of Clinical and Experimental Medicine, Orthopaedics and Sports Medicine . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Orthopaedic Centre, Department of Orthopaedics Linköping.
2010 (English)In: ACTA ORTHOPAEDICA, ISSN 1745-3674, Vol. 81, no 2, 236-238 p.Article in journal (Refereed) Published
Abstract [en]

Methods One third of the patients of the international trial were treated at Linkoping University Hospital. The multicenter trial did not evaluate early callus formation. We therefore made a blinded qualitative scoring of the callus at 5 weeks in our 27 patients. Callus formation was arbitrarily classified as rich, intermediate, or poor. Results 9 patients were classified as rich (none had received placebo, 3 low-dose teriparatide, and 6 high-dose teriparatide). 9 patients were classified as intermediate (1 had received placebo, 5 low-dose, and 3 high-dose). 9 patients were classified as poor (7 had received placebo, 1 low-dose, and 1 high-dose) (p andlt; 0.001). Interpretation This is a post hoc subgroup analysis of an outcome variable, which was not in the official protocol. The results must therefore be interpreted with caution. However, in combination with the results of the larger trial, the data suggest that radiographic quality at an early time point might be a sensitive variable, perhaps better than time to cortical continuity. Moreover, teriparatide appeared to improve early callus formation in distal radial fractures.

Place, publisher, year, edition, pages
Taylor and Francis / Informa Healthcare , 2010. Vol. 81, no 2, 236-238 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-55062DOI: 10.3109/17453671003761946ISI: 000276361700014OAI: oai:DiVA.org:liu-55062DiVA: diva2:315251
Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2010-04-28

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Aspenberg, PerJohansson, Torsten

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Orthopaedics and Sports Medicine Faculty of Health SciencesDepartment of Orthopaedics Linköping
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