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Selected neonatal outcomes in dizygotic twins after IVF versus non-IVF pregnancies
Lund University.
Linköping University, Department of Clinical and Experimental Medicine, Pediatrics . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Centre of Paediatrics and Gynecology and Obstetrics, Department of Paediatrics in Linköping.
National Board for Health and Welfare, Stockholm.
National Board for Health and Welfare, Stockholm.
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2010 (English)In: BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, ISSN 1470-0328, Vol. 117, no 6, 676-682 p.Article in journal (Refereed) Published
Abstract [en]

Objective To compare neonatal outcome among twins conceived after in vitro fertilisation (IVF) with that of spontaneously conceived twins. Design Comparison of different-sex (dizygotic) twins born after IVF with non-IVF dizygotic twins. Setting National health registers in Sweden. Population All births in Sweden during the period 1982-2007. Methods We studied gestational duration, lowest birthweight and birthweight difference in the twin pair, presence of one or two twins with a respiratory complication, and with jaundice in one or both twins. Risk estimates were calculated as odds ratios with adjustments for year of birth, maternal age, parity and smoking in pregnancy. Main outcome measures Gestational duration, birth weight, respiratory complications, jaundice. Results We studied 1545 pairs of dizygotic twins born after IVF, and 8675 pairs of dizygotic twins where IVF was not known to have occurred. The risk for preterm delivery before 32 weeks of gestation was significantly increased among dizygotic twin pairs born after IVF compared with non-IVF dizygotic twin pairs. No significant difference in low birthweight or birthweight difference within twin pairs was seen. There was an increased occurrence of twin pairs with respiratory problems or jaundice, but only the latter diagnosis occurred in a statistically significant excess. Conclusions The study confirms recent findings that IVF is associated with an increased risk for some neonatal complications, not only among singletons but also among twins.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd. , 2010. Vol. 117, no 6, 676-682 p.
Keyword [en]
Birthweight, IVF, jaundice, preterm birth, respiratory problems, twins
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-55059DOI: 10.1111/j.1471-0528.2010.02517.xISI: 000276509100005OAI: diva2:315257
Available from: 2010-04-28 Created: 2010-04-28 Last updated: 2010-04-28

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Finnström, Orvar
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Pediatrics Faculty of Health SciencesDepartment of Paediatrics in Linköping
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