Expression and significance of FXYD-3 protein in gastric adenocarcinoma
2010 (English)In: DISEASE MARKERS, ISSN 0278-0240, Vol. 28, no 2, 63-69 p.Article in journal (Refereed) Published
Objective: FXYD-3, also known as Mat-8, is a member of the FXYD protein family. It was reported that this protein can associate with and modify the transport properties of Na, K-ATPase, and may play an important role in a variety of physiological and pathological states. This protein is up-regulated in certain types of cancers (such as breast, prostate and pancreatic cancer), but down-regulated in other types of cancers (such as colon and kidney cancer). No study has been performed in gastric cancer; therefore, the aim of this project was to investigate FXYD-3 expression and its clinicopathological significance in gastric adenocarcinoma. Patients and methods: FXYD-3 protein was examined by immunohistochemistry in normal gastric mucous (n = 29) and gastric adenocarcinoma (n = 51), obtained from surgical resection of gastric cancer patients. Results: FXYD-3 protein was present in the cytoplasm of normal gastric epithelial cells or gastric cancer cells. The rate of FXYD-3 strong expression was significantly higher in cancer (51% of 51) than in normal mucosa (10% of 29, X-2=13.210, p andlt; 0.0001). FXYD-3 expressed strongly in ulcerative/infiltrating types of cancers compared to polypoid/fungating ones (X-2 = 5.765, p = 0.016). However, FXYD-3 expression was not correlated with patients gender, age, tumor size, lymph node status and histological grade (p andgt; 0.05). Conclosion: Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma.
Place, publisher, year, edition, pages
Ios Press , 2010. Vol. 28, no 2, 63-69 p.
FXYD-3, gastric cancer, immunohistochemistry
National CategoryMedical and Health Sciences
IdentifiersURN: urn:nbn:se:liu:diva-55055DOI: 10.3233/DMA-2010-0669ISI: 000276463200001OAI: oai:DiVA.org:liu-55055DiVA: diva2:315262
Zhen-Long Zhu, Zeng-Ren Zhao, Yu Zhang, Yan-Hong Yang, Zheng-Min Wang, Dong-Sheng Cui, Ming-Wei Wang, Joerg Kleeff, Hany Kayed, Bao-Yong Yan and Xiao-Feng Sun, Expression and significance of FXYD-3 protein in gastric adenocarcinoma, 2010, DISEASE MARKERS, (28), 2, 63-69.
Copyright: Ios Press