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Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides
Karolinska Institute.
Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology . Linköping University, Faculty of Health Sciences.
Linköping University, Department of Medicine and Health Sciences, Clinical Pharmacology . Linköping University, Faculty of Health Sciences.
2005 (English)In: Acta Psychiatrica Scandinavica, ISSN 0001-690X, E-ISSN 1600-0447, Vol. 111, no 4, 286-290 p.Article in journal (Refereed) Published
Abstract [en]

To test the hypothesis that selective serotonin reuptake inhibitor (SSRI) antidepressants may have a suicide emergent effect, particularly in children and adolescents. Detections of different antidepressants in the forensic toxicological screening of 14 857 suicides were compared with those in 26 422 cases of deaths by accident or natural causes in Sweden 1992-2000. There were 3411 detections of antidepressants in the suicides and 1538 in the controls. SSRIs had lower odds ratios than the other antidepressants. In the 52 suicides under 15 years, no SSRIs were detected. In 15-19-year age group, SSRIs had lower relative risk in suicides compared with non-SSRIs. The hypothesis that treatment of depressed individuals with SSRIs leads to an increased risk of suicide was not supported by this analysis of the total suicidal outcome of the nationwide use of SSRIs in Sweden over a period of 9 years, either in adults or in children or adolescents.

Place, publisher, year, edition, pages
Blackwell Publishing Ltd , 2005. Vol. 111, no 4, 286-290 p.
Keyword [en]
suicide; antidepressive agents; second-generation; paroxetine; toxicology; pharmacoepidemiology
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:liu:diva-55099DOI: 10.1111/j.1600-0447.2004.00504.xISI: 000227313300004OAI: oai:DiVA.org:liu-55099DiVA: diva2:315333
Available from: 2010-04-29 Created: 2010-04-29 Last updated: 2017-12-12

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Holmgren, PerAhlner, Johan

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CiteExportLink to record
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