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A fast and sensitive potentiometric glucose microsensor based on glucose oxidase coated ZnO nanowires grown on a thin silver wire
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.
Linköping University, Department of Science and Technology. Linköping University, The Institute of Technology.ORCID iD: 0000-0001-6235-7038
Lund University.
2010 (English)In: Sensors and actuators. B, Chemical, ISSN 0925-4005, Vol. 145, no 2, 869-874 p.Article in journal (Refereed) Published
Abstract [en]

In this study, a potentiometric glucose biosensor was fabricated by immobilization of glucose oxidase on to zinc oxide nanowires. Zinc oxide nanowires with 250-300 nm diameters and approximately 1.2 mu m lengths were grown on the surface of silver wires with a diameter of 250 mu m. Glucose oxidase (GOD) was electrostatically immobilized on the surface of the well aligned zinc oxide nanowires resulting in sensitive, selective, stable and reproducible glucose biosensors. The potentiometric response vs. Ag/AgCl reference electrode was found to be linear over a relatively wide logarithmic concentration range (0.5-1000 mu M) suitable for intracellular glucose detection. By applying a membrane on the sensor the linear range could be extended to 0.5 mu M to 10 mM, which increased the response time from less than 1 to 4s. On the other hand the membrane increased the sensor durability considerably. The sensor response was unaffected by normal concentrations of common interferents with glucose sensing such as uric acid and ascorbic acid.

Place, publisher, year, edition, pages
Elsevier Science B.V., Amsterdam. , 2010. Vol. 145, no 2, 869-874 p.
Keyword [en]
Glucose oxidase (GOD), Nafion membrane, Potentiometric biosensor, Electrochemical nanodevices, ZnO nanowires, Fast response
National Category
Engineering and Technology
URN: urn:nbn:se:liu:diva-55508DOI: 10.1016/j.snb.2009.12.072ISI: 000276589900039OAI: diva2:316254
Available from: 2010-04-30 Created: 2010-04-30 Last updated: 2014-01-15Bibliographically approved
In thesis
1. Fabrication and characterization of ZnO nanostructures for sensing and photonic device applications
Open this publication in new window or tab >>Fabrication and characterization of ZnO nanostructures for sensing and photonic device applications
2012 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Nanotechnology is an emerging inter-disciplinary paradigm which encompasses diverse fields of science and engineering converge at the nanoscale. This nanoscale science and nanostructure engineering have well demonstrated in the fabrication of sensors/transducers devices with faster response time and better sensitivity then the planer version of the sensor’s configurations. Nanotechnology is not just to grow/fabricate nanostructures by just mixing nanoscale materials together but it requires the ability to understand and to precisely manipulate and control of the developed nanomaterials in a useful way. Nanotechnology is aiding to substantially improve, even revolutionize, many technology and industry sectors like information technology, energy, environmental science, medicine/medical instrumentation, homeland security, food safety, and transportation, among many others. Such applications of nanotechnology are delivering in both expected and unexpected ways on nanotechnology’s promise to benefit the society.

The semiconductor ZnO with wide band gap (~ 3.37 eV) is a distinguish and unique material and its nanostructures have attracted great attention among the researchers due to its peculiar properties such as large exciton binding energy (60 meV) at room temperature, the high electron mobility, high thermal conductivity, good transparency and easiness of fabricating it in the different type of nanostructures. Based on all these fascinating properties, ZnO have been chosen as a suitable material for the fabrication of photonic, transducers/sensors, piezoelectric, transparent and spin electronics devices etc. The objective of the current study is to highlight the recent developments in materials and techniques for electrochemical sensing and hetrostructure light emitting diodes (LEDs) luminescence properties based on the different ZnO nanostructures. The sensor devices fabricated and characterized in the work were applied to determine and monitor the real changes of the chemical or biochemical species. We have successfully demonstrated the application of our fabricated devices as primary transducers/sensors for the determination of extracellular glucose and the glucose inside the human fat cells and frog cells using the potentiometric technique. Moreover, the fabricated ZnO based nanosensors have also been applied for the selective determination of uric acid, urea and metal ions successfully. This thesis relates specifically to zinc oxide nanostructure based electrochemical sensors and photonic device (LED) applications.

Place, publisher, year, edition, pages
Linköping: Linköping University Electronic Press, 2012. 76 p.
Linköping Studies in Science and Technology. Dissertations, ISSN 0345-7524 ; 1412
Nanotechnology, zinc oxide, nanowires/ nanorods, nanotubes, nanoporous/nanoflakes, electrochemical sensor and photonic devices
National Category
Electrical Engineering, Electronic Engineering, Information Engineering
urn:nbn:se:liu:diva-72774 (URN)978-91-7393-015-4 (ISBN)
Public defence
2012-01-17, K3, Kåkenhus, Campus Norrköping, Linköpings universitet, Norrköping, 10:15 (English)
Available from: 2011-12-07 Created: 2011-12-07 Last updated: 2014-01-15Bibliographically approved

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Usman Ali, Syed MNour, OmerWillander, Magnus
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