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Assessment of mucosal immunity to HIV-1
Institute for Tropical Medicine, Antwerp, Belgium .
University of Gothenburg.
Linköping University, Department of Clinical and Experimental Medicine, Molecular Virology. Linköping University, Faculty of Health Sciences.
University of Siena.
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2010 (English)In: EXPERT REVIEW OF VACCINES, ISSN 1476-0584, Vol. 9, no 4, 381-394 p.Article in journal (Refereed) Published
Abstract [en]

A key gap in the development and evaluation of HIV-1 vaccines is insufficient knowledge with regard to sampling techniques and assessment of mucosal immune responses required for early prevention and inhibition of viral dissemination. In an attempt to start bridging this gap, the EUROPRISE network of scientists working on HIV-1 vaccine and microbicide research organized a workshop with the aim to review the types of mucosal responses/biomarkers currently measured in mucosal immunology and to define how the mucosal responses/biomarkers are measured and/or the assays and sampling methods used. The Workshop addressed two critical questions: first whether, with current knowledge, it would be possible to define a consensus set of mucosal sampling methods to facilitate cross-species comparisons and ensure standardized implementation in clinical trials; second to determine the remaining challenges (technical and logistical) and their possible solutions for assessing mucosal responses to HIV-1 vaccines.

Place, publisher, year, edition, pages
Expert Reviews , 2010. Vol. 9, no 4, 381-394 p.
Keyword [en]
assessment, HIV vaccines, humans, macaques, mice, mucosal immunity, rabbits
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56454DOI: 10.1586/erv.10.21ISI: 000277214200012OAI: diva2:319256
Available from: 2010-05-17 Created: 2010-05-17 Last updated: 2014-10-03

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Hinkula, Jorma
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ReferencesLink to record
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