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Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder
Karolinska Institute.
Linköping University, Department of Clinical and Experimental Medicine, Psychiatry . Linköping University, Faculty of Health Sciences. Östergötlands Läns Landsting, Local Health Care Services in Central Östergötland, Department of Psychiatry.
Karolinska Institute and Hospital.
Uppsala University.
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2010 (English)In: JOURNAL OF PSYCHIATRY and NEUROSCIENCE, ISSN 1180-4882, Vol. 35, no 3, 195-199 p.Article in journal (Refereed) Published
Abstract [en]

Background: Patients with schizophrenia show elevated brain levels of the neuroactive tryptophan metabolite kynurenic acid (KYNA) This astrocyte] derived mediator acts as a neuroprotectant and modulates sensory gating and cognitive functiona We measured the levels of KYNA in the cerebrospinal fluid T vSyU of patients with bipolar disorder and healthy volunteers to investigate the putative involvement of KYNA in bipolar disorder. Methods: We obtained CSF by lumbar puncture from 23 healthy men and 31 euthymic men with bipolar disorder. We analyzed the samples using high] performance liquid chromatography. Results: Patients with bipolar disorder had increased levels of KYNA in their CSF compared with healthy volunteers (1.71 nM, standard error of the mean [SEM] cad, va dad, nM, SEM cacln p = 0.002. The levels of KYNA were positively correlated with age among bipolar patients but not healthy volunteersa Limitations: The influence of ongoing drug treatment among patients cannot be ruled outa We conducted our study during the euthymic phase of the diseasea Conclusion: Brain KYNA levels are increased in euthymic men with bipolar disorder. In addition, KYNA levels increased with age in these patientsa These findings indicate shared mechanisms between bipolar disorder and schizophrenia. Elevated levels of brain KYNA may provide further insight to the pathophysiology and progression of bipolar disordera

Place, publisher, year, edition, pages
Journal of Psychiatry and Neuroscience / Canadian Medical Association , 2010. Vol. 35, no 3, 195-199 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56451DOI: 10.1503/jpn.090180ISI: 000277127500006OAI: diva2:319261
Available from: 2010-05-17 Created: 2010-05-17 Last updated: 2010-05-17

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Samuelsson, Martin
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Psychiatry Faculty of Health SciencesDepartment of Psychiatry
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