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Genetic Risk Factors in Lupus Nephritis and IgA Nephropathy - No Support of an Overlap
Karolinska Institutet.
Karolinska Institutet.
Karolinska University Hospital.
Karolinska Institutet.
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2010 (English)In: PLOS ONE, ISSN 1932-6203, Vol. 5, no 5Article in journal (Refereed) Published
Abstract [en]

Background: IgA nephropathy (IgAN) and nephritis in Systemic Lupus Erythematosus (SLE) are two common forms of glomerulonephritis in which genetic findings are of importance for disease development. We have recently reported an association of IgAN with variants of TGFB1. In several autoimmune diseases, particularly in SLE, IRF5, STAT4 genes and TRAF1-C5 locus have been shown to be important candidate genes. The aim of this study was to compare genetic variants from the TGFB1, IRF5, STAT4 genes and TRAF1-C5 locus with susceptibility to IgAN and lupus nephritis in two Swedish cohorts. Patients and Methods: We genotyped 13 single nucleotide polymorphisms (SNPs) in four genetic loci in 1252 DNA samples from patients with biopsy proven IgAN or with SLE (with and without nephritis) and healthy age-and sex-matched controls from the same population in Sweden. Results: Genotype and allelic frequencies for SNPs from selected genes did not differ significantly between lupus nephritis patients and SLE patients without nephritis. In addition, haplotype analysis for seven selected SNPs did not reveal a difference for the SLE patient groups with and without nephritis. Moreover, none of these SPNs showed a significant difference between IgAN patients and healthy controls. IRF5 and STAT4 variants remained significantly different between SLE cases and healthy controls. In addition, the data did not show an association of TRAF1-C5 polymorphism with susceptibility to SLE in this Swedish population. Conclusion: Our data do not support an overlap in genetic susceptibility between patients with IgAN or SLE and reveal no specific importance of SLE associated SNPs for the presence of lupus nephritis.

Place, publisher, year, edition, pages
Public Library of Science (PLoS) , 2010. Vol. 5, no 5
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56520DOI: 10.1371/journal.pone.0010559ISI: 000277467900015OAI: diva2:320073

Original Publication: Mai Tuyet Vuong, Iva Gunnarsson, Sigrid Lundberg, Elisabet Svenungsson, Lars Wramner, Anders Fernström, Ann-Christine Syvanen, Lieu Thi Do, Stefan H. Jacobson and Leonid Padyukov, Genetic Risk Factors in Lupus Nephritis and IgA Nephropathy - No Support of an Overlap, 2010, PLOS ONE, (5), 5. Licensee: Public Library of Science (PLoS)

Available from: 2010-05-21 Created: 2010-05-21 Last updated: 2013-12-02

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Fernström, Anders
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NephrologyFaculty of Health SciencesDepartment of Nephrology
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