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Effect of Angiotensin-Converting Enzyme Inhibition on One-Year Mortality and Frequency of Repeat Acute Myocardial Infarction in Patients With Acute Myocardial Infarction
Karolinska University Hospital.
Karolinska University Hospital.
Uppsala Clinical Research Centre.
Karolinska University Hospital.
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2010 (English)In: AMERICAN JOURNAL OF CARDIOLOGY, ISSN 0002-9149, Vol. 105, no 9, 1229-1234 p.Article in journal (Refereed) Published
Abstract [en]

Controversy exists regarding whether all patients with acute myocardial infarction (AM!) benefit from angiotensin-converting enzyme inhibitors (ACEIs). We examined the association between ACEI treatment and mortality in a large, unselected population of patients with AMI. The present study included 105,224 patients with AMI who were not treated with ACEIs on admission. A logistic regression analysis, including 33 variables, calculated a propensity score for each patient to estimate the probability of receiving ACEIs at discharge, given the background. The association between ACEI treatment at discharge and the 1-year outcome was evaluated in prespecified subgroups using the Cox regression analyses, adjusting for the propensity score and medications at discharge. A total of 38,395 patients (36.5%) received ACEIs at discharge. After adjustment, ACEI treatment was associated with a 24% reduction in mortality (relative risk 0.76, 95% confidence interval 0.73 to 0.80). The benefit was largest in patients with a history or present signs of heart failure. In patients without heart failure, a significant benefit of ACEI treatment was seen only in patients with renal dysfunction (relative risk 0.69, 95% confidence interval 0.54 to 0.88). In the whole group, the risk of AMI decreased by 7% (relative risk 0.93, 95% confidence interval 0.90 to 0.96), with a larger effect seen in patients with ST-segment elevation AMI or systolic left ventricular dysfunction. In conclusion, in unselected patients with AMI, ACEI treatment was associated with a reduction in 1-year mortality, mainly in patients with heart failure or renal dysfunction, and a small reduction in the risk of reinfarction, mainly in patients with ST-segment elevation AMI or systolic left ventricular dysfunction.

Place, publisher, year, edition, pages
Elsevier Science B. V., Amsterdam , 2010. Vol. 105, no 9, 1229-1234 p.
National Category
Medical and Health Sciences
URN: urn:nbn:se:liu:diva-56693DOI: 10.1016/j.amjcard.2009.12.032ISI: 000277579600005OAI: diva2:321227
Available from: 2010-05-31 Created: 2010-05-31 Last updated: 2010-05-31

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Stenestrand, Ulf
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Cardiology Faculty of Health SciencesDepartment of Cardiology
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ReferencesLink to record
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